Document Detail

Cardiac thrombus in dilated cardiomyopathy. Relationship between left ventricular pathophysiology and left ventricular thrombus.
MedLine Citation:
PMID:  2724526     Owner:  NLM     Status:  MEDLINE    
The relationship between left ventricular thrombus and left ventricular dynamics in dilated cardiomyopathy (DCM) was studied by echocardiography and postmortem examination. The subjects were 57 patients with DCM, 40 were survival patients examined by echocardiography and 17 were autopsy patients. Systemic or pulmonary embolism occurred in 10 of 57 patients, 4 of 40 survival patients and 6 of 17 autopsy patients. Intracardiac thrombus was detected in 11 of 40 survival patients and was found in 8 of 17 autopsy patients. Left ventricular segmental wall motion abnormalities were observed in all 40 patients examined by two-dimensional echocardiography and apical dyskinesis or akinesis was observed more frequently in patients with left ventricular thrombus than in patients without left ventricular thrombus. Of 33 patients examined by pulsed Doppler echocardiography, Doppler ejection flow signals in the apical long axis view were recorded in 9% at the apex, in 17% at the middle portion and in 57% at the portion near the interventricular septal center. The signals at the portion near the interventricular septal center were recorded in only 2 patients with left ventricular thrombus but in 66% of patients without left ventricular thrombus. Systemic or pulmonary embolism and intracardiac thrombus occurred less frequently in patients treated with warfarin than in patients without warfarin. These results indicate that endomyocardial and blood flow disorders of the left ventricle play important roles in the occurrence of left ventricular thrombus and that anticoagulant therapy is useful for the prevention of systemic or pulmonary embolism and cardiac thrombus.
Y Yokota; H Kawanishi; M Hayakawa; T Kumaki; A Takarada; O Nakanishi; H Fukuzaki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Japanese heart journal     Volume:  30     ISSN:  0021-4868     ISO Abbreviation:  Jpn Heart J     Publication Date:  1989 Jan 
Date Detail:
Created Date:  1989-06-29     Completed Date:  1989-06-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401175     Medline TA:  Jpn Heart J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1-11     Citation Subset:  IM    
First Department of Internal Medicine, Kobe University School of Medicine, Japan.
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MeSH Terms
Cardiomyopathy, Dilated / complications*,  drug therapy
Coronary Disease / etiology*
Coronary Thrombosis / etiology*,  physiopathology,  prevention & control
Heart / physiopathology*
Heart Ventricles
Middle Aged
Stroke Volume
Warfarin / therapeutic use
Reg. No./Substance:

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