| Cardiac sympathetic nervous disintegrity is related to exercise intolerance in patients with chronic heart failure. | |
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MedLine Citation:
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PMID: 9853334 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this study was to clarify the relationship between cardiac sympathetic nervous activity assessed by 123I-MIBG imaging and exercise capacity in patients with congestive heart failure. The subjects were 24 patients with heart failure (NYHA class II to III) and 7 normal controls. A dose of 148 MBq of 123I-MIBG was administered intravenously, and 5-min anterior planar images were obtained 20 min (early) and 4 h (delayed) after the injection of 123I-MIBG. Regions of interest were placed over the left ventricle and mediastinum, and the heart-to-mediastinum ratio (H/M ratio) was calculated as a fraction of the mean counts per pixel in the heart divided by those in the mediastinum. The washout rate from the myocardium was determined by: (early counts delayed counts) x 100/early counts (%). Treadmill exercise tests were performed using a ramp method within 1 week of the 123I-MIBG studies. During exercise, expired gas was analysed, and peak VO2 and VO2 at the anaerobic threshold (ATVO2) were measured. A significant linear correlation was found between the H/M ratio on delayed 123I-MIBG images and exercise duration (r = 0.48, P < 0.05), peak VO2 (r = 0.49, P < 0.05) and ATVO2 (r = 0.56, P < 0.01). The washout rate of 123I-MIBG was inversely correlated with exercise duration (r = -0.45, P < 0.05), peak VO2 (r = -0.51, P < 0.01), and ATVO2 (r = -0.50, P < 0.05). In conclusion, enhanced cardiac sympathetic nervous activity relates to exercise intolerance in patients with congestive heart failure. The non-invasive assessment of cardiac sympathetic nervous activity by 123I-MIBG can predict exercise capacity in human heart failure. |
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Authors:
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H Atsumi; Y Takeishi; S Fujiwara; H Tomoike |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nuclear medicine communications Volume: 19 ISSN: 0143-3636 ISO Abbreviation: Nucl Med Commun Publication Date: 1998 May |
Date Detail:
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Created Date: 1999-01-08 Completed Date: 1999-01-08 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8201017 Medline TA: Nucl Med Commun Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 451-6 Citation Subset: IM |
Affiliation:
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First Department of Internal Medicine, Yamagata University School of Medicine, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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diagnostic use Autonomic Nervous System Diseases / physiopathology*, radionuclide imaging* Blood Pressure / physiology Chronic Disease Exercise Test Exercise Tolerance / physiology* Female Heart Failure / physiopathology*, radionuclide imaging* Heart Rate / physiology Humans Male Middle Aged Norepinephrine / blood Oxygen Consumption Radiopharmaceuticals / diagnostic use Sympathetic Nervous System / physiopathology*, radionuclide imaging* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 51-41-2/Norepinephrine; 77679-27-7/3-Iodobenzylguanidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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