Document Detail

Cardiac sympathetic nervous disintegrity is related to exercise intolerance in patients with chronic heart failure.
MedLine Citation:
PMID:  9853334     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to clarify the relationship between cardiac sympathetic nervous activity assessed by 123I-MIBG imaging and exercise capacity in patients with congestive heart failure. The subjects were 24 patients with heart failure (NYHA class II to III) and 7 normal controls. A dose of 148 MBq of 123I-MIBG was administered intravenously, and 5-min anterior planar images were obtained 20 min (early) and 4 h (delayed) after the injection of 123I-MIBG. Regions of interest were placed over the left ventricle and mediastinum, and the heart-to-mediastinum ratio (H/M ratio) was calculated as a fraction of the mean counts per pixel in the heart divided by those in the mediastinum. The washout rate from the myocardium was determined by: (early counts delayed counts) x 100/early counts (%). Treadmill exercise tests were performed using a ramp method within 1 week of the 123I-MIBG studies. During exercise, expired gas was analysed, and peak VO2 and VO2 at the anaerobic threshold (ATVO2) were measured. A significant linear correlation was found between the H/M ratio on delayed 123I-MIBG images and exercise duration (r = 0.48, P < 0.05), peak VO2 (r = 0.49, P < 0.05) and ATVO2 (r = 0.56, P < 0.01). The washout rate of 123I-MIBG was inversely correlated with exercise duration (r = -0.45, P < 0.05), peak VO2 (r = -0.51, P < 0.01), and ATVO2 (r = -0.50, P < 0.05). In conclusion, enhanced cardiac sympathetic nervous activity relates to exercise intolerance in patients with congestive heart failure. The non-invasive assessment of cardiac sympathetic nervous activity by 123I-MIBG can predict exercise capacity in human heart failure.
H Atsumi; Y Takeishi; S Fujiwara; H Tomoike
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuclear medicine communications     Volume:  19     ISSN:  0143-3636     ISO Abbreviation:  Nucl Med Commun     Publication Date:  1998 May 
Date Detail:
Created Date:  1999-01-08     Completed Date:  1999-01-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  451-6     Citation Subset:  IM    
First Department of Internal Medicine, Yamagata University School of Medicine, Japan.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use
Autonomic Nervous System Diseases / physiopathology*,  radionuclide imaging*
Blood Pressure / physiology
Chronic Disease
Exercise Test
Exercise Tolerance / physiology*
Heart Failure / physiopathology*,  radionuclide imaging*
Heart Rate / physiology
Middle Aged
Norepinephrine / blood
Oxygen Consumption
Radiopharmaceuticals / diagnostic use
Sympathetic Nervous System / physiopathology*,  radionuclide imaging*
Reg. No./Substance:
0/Radiopharmaceuticals; 51-41-2/Norepinephrine; 77679-27-7/3-Iodobenzylguanidine

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