Document Detail

Cardiac sympathetic nerve stimulation triggers coronary t-PA release.
MedLine Citation:
PMID:  12714432     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This study was undertaken to determine whether stimulation of sympathetic cardiac nerves induces release of the thrombolytic enzyme tissue-type plasminogen activator (t-PA) in the coronary vascular bed. METHODS AND RESULTS: Anesthetized pigs were studied in an open chest model. Bilateral vagotomy was performed, and sympathetic cardiac nerves were activated by electrical stimulation (1 and 8 Hz). To evaluate possible mediating effects of increased heart rate and enhanced local blood flow, tachycardia was induced by pacing and hyperemia by local infusion of sodium nitroprusside and clevedipine. Furthermore, to study the effects of alpha- and beta-adrenergic receptor stimulation, phenylephrine and isoprenaline were infused locally. In response to low- and high-frequency sympathetic stimulation, mean coronary net release of total t-PA increased approximately 6- and 25-fold, respectively. Active t-PA showed a similar response pattern. Neither tachycardia nor coronary hyperemia stimulated t-PA release. In contrast, beta-adrenergic stimulation by isoprenaline induced an approximately 6-fold increase in coronary t-PA release, whereas no significant change in release rates occurred in response to alpha-adrenergic stimulation by phenylephrine. CONCLUSIONS: Stimulation of cardiac sympathetic nerves induces a marked coronary release of t-PA, and part of this response may be mediated through stimulation of beta-adrenergic receptors.
Jan-Arne Björkman; Sverker Jern; Christina Jern
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2003-04-24
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  23     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2003 Jun 
Date Detail:
Created Date:  2003-06-16     Completed Date:  2004-02-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1091-7     Citation Subset:  IM    
AstraZeneca R&D Mölndal, Mölndal, Sweden.
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MeSH Terms
Adrenergic alpha-Agonists / pharmacology
Adrenergic beta-Agonists / pharmacology
Blood Pressure / drug effects
Calcium Channel Blockers / pharmacology
Coronary Circulation / drug effects
Coronary Vessels / drug effects,  secretion*
Electric Stimulation
Endothelium, Vascular / drug effects,  secretion*
Heart / innervation*
Heart Rate / drug effects
Hyperemia / physiopathology
Isoproterenol / pharmacology
Nitric Oxide Donors / pharmacology
Nitroprusside / pharmacology
Phenylephrine / pharmacology
Pyridines / pharmacology
Sympathetic Nervous System / physiology*
Tachycardia / physiopathology
Tissue Plasminogen Activator / secretion*
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Agonists; 0/Calcium Channel Blockers; 0/Nitric Oxide Donors; 0/Pyridines; 0/clevidipine; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol; EC Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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