| Cardiac sympathetic nerve stimulation triggers coronary t-PA release. | |
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MedLine Citation:
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PMID: 12714432 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: This study was undertaken to determine whether stimulation of sympathetic cardiac nerves induces release of the thrombolytic enzyme tissue-type plasminogen activator (t-PA) in the coronary vascular bed. METHODS AND RESULTS: Anesthetized pigs were studied in an open chest model. Bilateral vagotomy was performed, and sympathetic cardiac nerves were activated by electrical stimulation (1 and 8 Hz). To evaluate possible mediating effects of increased heart rate and enhanced local blood flow, tachycardia was induced by pacing and hyperemia by local infusion of sodium nitroprusside and clevedipine. Furthermore, to study the effects of alpha- and beta-adrenergic receptor stimulation, phenylephrine and isoprenaline were infused locally. In response to low- and high-frequency sympathetic stimulation, mean coronary net release of total t-PA increased approximately 6- and 25-fold, respectively. Active t-PA showed a similar response pattern. Neither tachycardia nor coronary hyperemia stimulated t-PA release. In contrast, beta-adrenergic stimulation by isoprenaline induced an approximately 6-fold increase in coronary t-PA release, whereas no significant change in release rates occurred in response to alpha-adrenergic stimulation by phenylephrine. CONCLUSIONS: Stimulation of cardiac sympathetic nerves induces a marked coronary release of t-PA, and part of this response may be mediated through stimulation of beta-adrenergic receptors. |
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Authors:
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Jan-Arne Björkman; Sverker Jern; Christina Jern |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-04-24 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 23 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-16 Completed Date: 2004-02-26 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1091-7 Citation Subset: IM |
Affiliation:
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AstraZeneca R&D Mölndal, Mölndal, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenergic alpha-Agonists
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pharmacology Adrenergic beta-Agonists / pharmacology Animals Blood Pressure / drug effects Calcium Channel Blockers / pharmacology Coronary Circulation / drug effects Coronary Vessels / drug effects, secretion* Electric Stimulation Endothelium, Vascular / drug effects, secretion* Female Heart / innervation* Heart Rate / drug effects Hyperemia / physiopathology Isoproterenol / pharmacology Male Nitric Oxide Donors / pharmacology Nitroprusside / pharmacology Phenylephrine / pharmacology Pyridines / pharmacology Swine Sympathetic Nervous System / physiology* Tachycardia / physiopathology Tissue Plasminogen Activator / secretion* |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic alpha-Agonists; 0/Adrenergic beta-Agonists; 0/Calcium Channel Blockers; 0/Nitric Oxide Donors; 0/Pyridines; 0/clevidipine; 15078-28-1/Nitroprusside; 59-42-7/Phenylephrine; 7683-59-2/Isoproterenol; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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