Document Detail


Cardiac sympathetic denervation preceding motor signs in Parkinson disease.
MedLine Citation:
PMID:  19376983     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[(18)F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.
Authors:
David S Goldstein; Yehonatan Sharabi; Barbara I Karp; Oladi Bentho; Ahmed Saleem; Karel Pacak; Graeme Eisenhofer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Cleveland Clinic journal of medicine     Volume:  76 Suppl 2     ISSN:  1939-2869     ISO Abbreviation:  Cleve Clin J Med     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-20     Completed Date:  2009-07-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703441     Medline TA:  Cleve Clin J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S47-50     Citation Subset:  -    
Affiliation:
Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10, Room 6N252, Bethesda, MD 20892-1620, USA. goldsteind@ninds.nih.gov
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