| Cardiac sympathetic denervation preceding motor signs in Parkinson disease. | |
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MedLine Citation:
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PMID: 19376983 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[(18)F]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD. |
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Authors:
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David S Goldstein; Yehonatan Sharabi; Barbara I Karp; Oladi Bentho; Ahmed Saleem; Karel Pacak; Graeme Eisenhofer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural |
Journal Detail:
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Title: Cleveland Clinic journal of medicine Volume: 76 Suppl 2 ISSN: 1939-2869 ISO Abbreviation: Cleve Clin J Med Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-20 Completed Date: 2009-07-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8703441 Medline TA: Cleve Clin J Med Country: United States |
Other Details:
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Languages: eng Pagination: S47-50 Citation Subset: - |
Affiliation:
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Clinical Neurocardiology Section, NINDS, NIH, 10 Center Drive MSC-1620, Building 10, Room 6N252, Bethesda, MD 20892-1620, USA. goldsteind@ninds.nih.gov |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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