Document Detail

Cardiac sympathetic denervation does not change the load dependence of the left ventricular end-systolic pressure/volume relationship in dogs.
MedLine Citation:
PMID:  8134259     Owner:  NLM     Status:  MEDLINE    
It has been shown that in the intact canine heart the left-ventricular end-systolic pressure/volume relation (ESPVR) depends on loading conditions: an increase in arterial vascular resistance causes a leftwards shift and a steeper slope of the ESPVR, suggesting an increased inotropic state. Our purpose was to investigate the possible contribution of the sympathetic nervous system to this load sensitivity of the ESPVR, using intact, but denervated, hearts with normal coronary perfusion and afterload. We used two types of loading intervention: venous volume infusion and gradual occlusion of the descending aorta. ESPVRs were obtained in six anaesthetized open-chest dogs, both before and after bilateral ablation of the stellate ganglia. To exclude the influence of heart rate changes, bilateral vagotomy was performed and the heart was paced. The absence of (unpaced) heart rate changes in response to pressure alterations was used to confirm total denervation. Left ventricular pressure was measured with a micromanometer and volume with a conductance catheter. ESPVRs were essentially linear and characterized by their slope (Ees) and volume intercept at 12 kPa (V12). We found that Ees (P < 0.0001) and V12 (P < 0.05) were both significantly different during pressure and volume interventions (0.67 +/- 0.29 and 0.41 +/- 0.18 kPa/ml for Ees and 16.2 +/- 8.2 and 18.2 +/- 8.4 ml for V12 respectively). Denervation did not significantly affect the parameters of the ESPVR obtained by either volume infusion or aortic occlusion. Two-way analysis of variance revealed no significant interactive effect between denervation and intervention, indicating that the sympathetic nervous system does not influence the load dependency of the ESPVR.(ABSTRACT TRUNCATED AT 250 WORDS)
I B Schipper; P Steendijk; R J Klautz; E T van der Velde; J Baan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  425     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-15     Completed Date:  1994-04-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  426-33     Citation Subset:  IM; S    
Department of Cardiology, University Hospital Leiden, The Netherlands.
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MeSH Terms
Analysis of Variance
Blood Pressure*
Heart Conduction System / physiology*
Stellate Ganglion / physiology
Stroke Volume*
Sympathetic Nervous System / physiology*
Ventricular Function, Left*

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