Document Detail


Cardiac survival in anoxia-tolerant vertebrates: An electrophysiological perspective.
MedLine Citation:
PMID:  18589002     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Certain vertebrates, such as freshwater turtles of the genus Chrysemys and Trachemys and crucian carp (Carassius carassius), have anoxia-tolerant hearts that continue to function throughout prolonged periods of anoxia (up to many months) due to successful balancing of cellular ATP supply and demand. In the present review, we summarize the current and limited understanding of the cellular mechanisms underlying this cardiac anoxia tolerance. What emerges is that cold temperature substantially modifies cardiac electrophysiology to precondition the heart for winter anoxia. Intrinsic heart rate is slowed and density of sarcolemmal ion currents substantially modified to alter cardiac action potential (AP) characteristics. These changes depress cardiac activity and reduce the energetic costs associated with ion pumping. In contrast, anoxia per se results in limited changes to cardiac AP shape or ion current densities in turtle and crucian carp, suggesting that anoxic modifications of cardiac electrophysiology to reduce ATP demand are not extensive. Additionally, as knowledge of cellular physiology in non-mammalian vertebrates is still in its infancy, we briefly discuss the cellular defense mechanisms towards the acidosis that accompanies anoxia as well as mammalian cardiac models of hypoxia/ischemia tolerance. By examining if fundamental cellular mechanisms have been conserved during the evolution of anoxia tolerance we hope to have provided a framework for the design of future experiments investigating cardiac cellular mechanisms of anoxia survival.
Authors:
Jonathan A W Stecyk; Gina L Galli; Holly A Shiels; Anthony P Farrell
Publication Detail:
Type:  Journal Article; Review     Date:  2008-06-05
Journal Detail:
Title:  Comparative biochemistry and physiology. Toxicology & pharmacology : CBP     Volume:  148     ISSN:  1532-0456     ISO Abbreviation:  Comp. Biochem. Physiol. C Toxicol. Pharmacol.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-11-17     Completed Date:  2009-02-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100959500     Medline TA:  Comp Biochem Physiol C Toxicol Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  339-54     Citation Subset:  IM    
Affiliation:
Physiology Programme, Department of Molecular Biosciences, University of Oslo, PO Box 1041, N-0316, Oslo, Norway. jonathan.stecyk@imbv.uio.no
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MeSH Terms
Descriptor/Qualifier:
Action Potentials*
Adaptation, Physiological
Adenosine Triphosphate / metabolism
Animals
Anoxia / metabolism*,  physiopathology
Carps / metabolism
Cold Temperature
Energy Metabolism*
Heart Rate*
Hemodynamics*
Hydrogen-Ion Concentration
Ion Channels / metabolism
Myocardium / metabolism*
Sarcolemma / metabolism
Time Factors
Turtles / metabolism
Chemical
Reg. No./Substance:
0/Ion Channels; 56-65-5/Adenosine Triphosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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