| Cardiac substances that influence blood-pressure. I. Identification of the agent that lowers blood-pressure in anaesthetized rats. | |
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MedLine Citation:
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PMID: 6517936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extracts of the atrium of the mammalian heart contain a natriuretic factor which may be associated with the atrium-specific granules. It has often been observed that the intravenous injection of a crude atrial extract into anaesthetized rats, causes a transient decrease in blood-pressure. In rabbits, this activity is present in stored aqueous extracts prepared from both atrial and ventricular tissue. The hypotensive activity, which can be readily separated from the natriuretic factor, is mainly due to the presence of adenosine and its derivatives, of which 5'-adenosine monophosphate is the major contributor. However, an extract from rabbit atrial muscle, carefully prepared under stringent conditions, caused a rapid and striking increase in blood-pressure, an activity that could not be detected in ventricular tissue. |
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Authors:
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J J Nieuwenhuis; B C Labuschagne; J J Theron; R P Biagio |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 125 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1984 Dec |
Date Detail:
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Created Date: 1985-02-14 Completed Date: 1985-02-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1074-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects* Chromatography, Gel Dogs Heart Atria / analysis Male Myocardium / analysis* Rabbits Spectrophotometry, Ultraviolet Tissue Extracts / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Tissue Extracts |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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