Document Detail


Cardiac substances that influence blood-pressure. I. Identification of the agent that lowers blood-pressure in anaesthetized rats.
MedLine Citation:
PMID:  6517936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Extracts of the atrium of the mammalian heart contain a natriuretic factor which may be associated with the atrium-specific granules. It has often been observed that the intravenous injection of a crude atrial extract into anaesthetized rats, causes a transient decrease in blood-pressure. In rabbits, this activity is present in stored aqueous extracts prepared from both atrial and ventricular tissue. The hypotensive activity, which can be readily separated from the natriuretic factor, is mainly due to the presence of adenosine and its derivatives, of which 5'-adenosine monophosphate is the major contributor. However, an extract from rabbit atrial muscle, carefully prepared under stringent conditions, caused a rapid and striking increase in blood-pressure, an activity that could not be detected in ventricular tissue.
Authors:
J J Nieuwenhuis; B C Labuschagne; J J Theron; R P Biagio
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  125     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1984 Dec 
Date Detail:
Created Date:  1985-02-14     Completed Date:  1985-02-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1074-81     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / drug effects*
Chromatography, Gel
Dogs
Heart Atria / analysis
Male
Myocardium / analysis*
Rabbits
Spectrophotometry, Ultraviolet
Tissue Extracts / pharmacology*
Chemical
Reg. No./Substance:
0/Tissue Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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