Document Detail


Cardiac structure and apnea/hypopnea index in patients with arterial hypertension and excessive weight.
MedLine Citation:
PMID:  16931894     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: Arterial hypertension is frequently associated with sleep apnea, excessive weight, and with changes in the echocardiographic characteristics of the left cardiac chambers. The present investigation was conducted in order to search for a possible relation between left cardiac structure and sleep apnea magnitude in patients with arterial hypertension and excessive weight. METHODS: A group of 56 patients with arterial hypertension and mean body mass index of 30.6 +/- 3.8 (weight in kilograms/height in meters squared) was studied by echocardiography, sleep study and electrocardiography. RESULTS: A relatively high mean apnea-hypopnea index (AHI) was found (17.9 +/- 17.2 episodes/h sleep), but this parameter was not found to be correlated with cardiac echocardiographic diameters. Patients with an AHI <5 episodes/h had smaller mean values for left atrial diameter, left ventricular mass index and left ventricular relative wall thickness, when compared to patients with an AHI value of > or =5. The mean corrected QT interval was found to be longer in female patients, whereas left ventricular end-diastolic diameter was smaller than in male patients. CONCLUSION: In patients with arterial hypertension and excessive weight, significant apnea seems to be very common. In such patients, left ventricle wall thickness, left ventricle mass index and the left atrium diameter may act as surrogate markers for significant sleep apnea. Thus, the hypothesis is raised that hypoxia may lead to changes in heart structure.
Authors:
José Pedro L Nunes; Nuno Pardal Oliveira
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Publication Detail:
Type:  Journal Article     Date:  2006-08-24
Journal Detail:
Title:  Kidney & blood pressure research     Volume:  29     ISSN:  1420-4096     ISO Abbreviation:  Kidney Blood Press. Res.     Publication Date:  2006  
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9610505     Medline TA:  Kidney Blood Press Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Copyright Information:
Copyright 2006 S. Karger AG, Basel.
Affiliation:
Faculdade de Medicina do Porto, Porto, Portugal. jplnunes@med.up.pt
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MeSH Terms
Descriptor/Qualifier:
Aged
Anoxia / physiopathology
Basal Metabolism / physiology
Echocardiography
Female
Heart Ventricles / pathology*
Humans
Hypertension / physiopathology*
Male
Middle Aged
Obesity / physiopathology*
Sleep Apnea Syndromes / physiopathology*
Statistics, Nonparametric

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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