Document Detail

Cardiac structure and function in the obese: a cardiovascular magnetic resonance imaging study.
MedLine Citation:
PMID:  12882074     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Obesity is a major health problem in the Western world. Among obese subjects cardiac pathology is common, but conventional noninvasive imaging modalities are often suboptimal for detailed evaluation of cardiac structure and function. We investigated whether cardiovascular magnetic resonance imaging (CMR) can better characterize possible cardiac abnormalities associated with obesity, in the absence of other confounding comorbidities. METHODS: In this prospective cross-sectional study, CMR was used to quantify left and right ventricular volumes, ejection fraction, mass, cardiac output, and apical left ventricular rotation in 25 clinically healthy obese men and 25 age-matched lean controls. RESULTS: Obese subjects had higher left ventricular mass (203 +/- 38 g vs. 163 +/- 22 g, p < 0.001), end-diastolic volume (176 +/- 29 mL vs. 156 +/- 25 mL, p < 0.05), and cardiac output (8.2 +/- 1.2 L/min vs. 6.4 +/- 1.3 L/min, p < 0.001). The obese also had increased right ventricular mass (105 +/- 25 g vs. 87 +/- 18 g, p < 0.005) and end-diastolic volume (179 +/- 36 mL vs. 155 +/- 28 mL, p < 0.05). When indexed for height, differences in left and right ventricular mass, and left ventricular end-diastolic volume remained significant. Apical left ventricular rotation and rotational velocity patterns were also different between obese and lean subjects. CONCLUSIONS: Obesity is independently associated with remodeling of the heart. Cardiovascular magnetic resonance imaging identifies subtle cardiac abnormalities and may be the preferred imaging technique to evaluate cardiac structure and function in the obese.
Peter G Danias; Nicholas A Tritos; Matthias Stuber; Kraig V Kissinger; Carol J Salton; Warren J Manning
Related Documents :
16449874 - Relationships between sports-specific characteristics of athlete's heart and maximal ox...
22963444 - Cardioprotection against ischaemia/reperfusion by vitamins c and e plus n-3 fatty acids...
19847054 - Left ventricular geometry and rheological properties of erythrocytes in patients at car...
14671464 - Relationship of electrocardiographic left ventricular hypertrophy to mortality and card...
1395204 - Triggered activity as arrhythmogenic mechanism after myocardial infarction: clinical an...
21854444 - Tissue doppler derived mechanical dyssynchrony does not change after cardiac resynchron...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance     Volume:  5     ISSN:  1097-6647     ISO Abbreviation:  J Cardiovasc Magn Reson     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-28     Completed Date:  2003-11-20     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815616     Medline TA:  J Cardiovasc Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  431-8     Citation Subset:  IM    
Division of Cardiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Analysis of Variance
Cross-Sectional Studies
Heart / physiopathology*
Imaging, Three-Dimensional
Magnetic Resonance Imaging / methods*
Obesity / physiopathology*
Prospective Studies
Statistics, Nonparametric
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Age-related changes in myocardial relaxation using three-dimensional tagged magnetic resonance imagi...
Next Document:  Rapid evaluation of right and left ventricular function and mass using real-time true-FISP cine MR i...