Document Detail

Cardiac structure and function in normal pregnancy.
MedLine Citation:
PMID:  23000697     Owner:  NLM     Status:  Publisher    
PURPOSE OF REVIEW: To review the published data on maternal cardiac adaptation to pregnancy. RECENT FINDINGS: Normal pregnancy is characterized by significant changes in the cardiovascular system. Studies on systemic arterial system and heart remodelling in pregnancy provide somewhat uniform results. In normal pregnancy, left ventricle mass, cardiac output and arterial compliance increase, whereas total vascular resistance decreases. In contrast, findings on left ventricular systolic and diastolic chamber and myocardial function are conflicting. SUMMARY: The major limitation of earlier studies on left ventricular systolic function is the use of ejection-phase indices that are dependent on loading conditions. Even when tissue Doppler velocity and deformation indices were measured, studies interpreted diastolic indices in isolation, rather than using validated diagnostic algorithms which account for the interdependency of cardiac events. Furthermore, the strong age-dependency of diastolic function indices was not accounted for in the majority of assessments and none of the studies diagnose or grade diastolic dysfunction. Future studies should aim to use appropriate control individuals, age-adjusted cutoff of cardiac diastolic indices and extended tissue Doppler velocity and deformation indices to provide objective information about chamber and myocardial function.
Karen Melchiorre; Rajan Sharma; Basky Thilaganathan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-20
Journal Detail:
Title:  Current opinion in obstetrics & gynecology     Volume:  -     ISSN:  1473-656X     ISO Abbreviation:  Curr. Opin. Obstet. Gynecol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-9-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007264     Medline TA:  Curr Opin Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aFetal Maternal Medicine Unit, Department of Obstetrics and Gynecology, St George's Hospital, University of London, London, United Kingdom bDepartment of Obstetrics and Gynecology, Santo Spirito Hospital, Pescara, Italy cDepartment of Cardiology and Cardiothoracic Surgery, St George's Hospital, University of London, London, United Kingdom.
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