Document Detail


Cardiac stress-rest single-photon emission computed tomography with technetium 99m-labeled tetrofosmin: influence of washout kinetics on regional myocardial uptake values of the rest study with a 1-day protocol.
MedLine Citation:
PMID:  9278876     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The purpose of this study was to evaluate (1) the washout kinetics of 99mTc-labeled tetrofosmin, separately for myocardium with normal and reduced perfusion, and (2) its influence on quantitative analysis in a 1-day stress-rest protocol. METHODS AND RESULTS: Twenty-five patients with angiographically proved coronary artery disease underwent bicycle exercise stress testing with injection of 200 MBq 99mTc-labeled tetrofosmin and first single-photon emission computed tomographic (SPECT) imaging 40 minutes after injection. A second SPECT was acquired 2.3 +/- 0.4 hours after the first one immediately before rest injection of 800 MBq 99mTc-labeled tetrofosmin. The rest (third) SPECT was acquired 15 minutes thereafter. The relative washout fraction per time (WOFt) was calculated assuming linear washout kinetics. Thirty-three regional uptake values per study were calculated, normalized to the perfusion maximum (100%) in either the postexercise SPECT and the rest SPECT, for the latter with and without correction of remaining counts from stress injection. In regions with normal perfusion, WOFt was 11.5% +/- 3.5% per hour. In regions with markedly reduced perfusion (relative uptake < 50%, WOFt was 8.3% +/- 9.9% per hour. The highest variation of the relative uptake values between rest SPECT with and without correction of remaining counts from stress injection was 5.4% +/- 3.5% in regions with stress-induced ischemia. CONCLUSION: To use a 1-day protocol with a stress-rest radioactivity ratio of 1:4 and an interval of more than 2 hours between the examinations, a correction for remaining counts from stress injection seems not to be necessary for the quantitative analysis of rest SPECT.
Authors:
G Schulz; E Ostwald; H J Kaiser; J vom Dahl; E Kleinhans; U Buell
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology     Volume:  4     ISSN:  1071-3581     ISO Abbreviation:  J Nucl Cardiol     Publication Date:    1997 Jul-Aug
Date Detail:
Created Date:  1997-10-09     Completed Date:  1997-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9423534     Medline TA:  J Nucl Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  298-301     Citation Subset:  IM    
Affiliation:
Department of Nuclear Medicine, Aachen University of Technology, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Coronary Disease / radionuclide imaging*
Female
Heart / radionuclide imaging*
Humans
Male
Middle Aged
Organophosphorus Compounds / diagnostic use*
Organotechnetium Compounds / diagnostic use*
Tomography, Emission-Computed, Single-Photon*
Chemical
Reg. No./Substance:
0/Organophosphorus Compounds; 0/Organotechnetium Compounds; 0/technetium Tc 99m 1,2-bis(bis(2-ethoxyethyl)phosphino)ethane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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