Document Detail


Cardiac side population cells: moving toward the center stage in cardiac regeneration.
MedLine Citation:
PMID:  22581921     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the past decade, extensive work in animal models and humans has identified the presence of adult cardiac progenitor cells, capable of cardiomyogenic differentiation and likely contributors to cardiomyocyte turnover during normal development and disease. Among cardiac progenitor cells, there is a distinct subpopulation, termed "side population" (SP) progenitor cells, identified by their unique ability to efflux DNA binding dyes through an ATP-binding cassette transporter. This review highlights the literature on the isolation, characterization, and functional relevance of cardiac SP cells. We review the initial discovery of cardiac SP cells in adult myocardium as well as their capacity for functional cardiomyogenic differentiation and role in cardiac regeneration after myocardial injury. Finally, we discuss recent advances in understanding the molecular regulators of cardiac SP cell proliferation and differentiation, as well as likely future areas of investigation required to realize the goal of effective cardiac regeneration.
Authors:
Kazumasa Unno; Mohit Jain; Ronglih Liao
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  110     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-05-14     Completed Date:  2012-07-10     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1355-63     Citation Subset:  IM    
Affiliation:
Cardiovascular Division, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult Stem Cells / physiology*
Animals
Cell Differentiation
Cell Proliferation
Heart / physiology*
Heart Diseases / physiopathology*,  therapy
Humans
Myocardium / cytology*
Regeneration / physiology*
Side-Population Cells / cytology*
Grant Support
ID/Acronym/Agency:
HL086967/HL/NHLBI NIH HHS; HL093148/HL/NHLBI NIH HHS; HL099173/HL/NHLBI NIH HHS; KO8 HL107451/HL/NHLBI NIH HHS; R01 HL086967/HL/NHLBI NIH HHS; R01 HL093148/HL/NHLBI NIH HHS; R01 HL099073/HL/NHLBI NIH HHS
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