Document Detail

Cardiac side effects of molecular targeted therapies: Towards a better dialogue between oncologists and cardiologists.
MedLine Citation:
PMID:  21330149     Owner:  NLM     Status:  Publisher    
Molecular targeted therapies (MTTs) have become a major component of modern management of various hematological and solid malignancies. However, some MTTs have been associated with cardiotoxicity. MTT-induced cardiovascular side effects include left ventricular systolic dysfunction, heart failure, conduction abnormalities, acute coronary syndrome, and hypertension. One of the most threatening complications of MTT, and notably of angiogenic inhibitors, is QT prolongation with the risk of torsades de pointe and sudden death. The precise incidence of cardiovascular events associated with MTT as well as their reversibility are unknown. Here, we summarize what is known about the cardiotoxicity of MTT, emphasizing MTTs that target tyrosine kinases. We have tried to provide both the basic mechanisms underlying specific cardiotoxicities (such as the interruption of specific signaling pathways leading to cardiomyocyte dysfunction and/or death), and offer guidance regarding the optimal way to detect and treat these cardiotoxicities.
Stephane Ederhy; Hassan Izzedine; Christophe Massard; Ghislaine Dufaitre; Jean Philippe Spano; Gerard Milano; Catherine Meuleman; Benjamin Besse; Franck Boccara; David Kahyat; Ariel Cohen; Jean Charles Soria
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-15
Journal Detail:
Title:  Critical reviews in oncology/hematology     Volume:  -     ISSN:  1879-0461     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8916049     Medline TA:  Crit Rev Oncol Hematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
Saint-Antoine Hospital and University Pierre et Marie Curie VI, Paris, France.
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