Document Detail

Cardiac septation: a late contribution of the embryonic primary myocardium to heart morphogenesis.
MedLine Citation:
PMID:  12142341     Owner:  NLM     Status:  MEDLINE    
Heart morphogenesis comprises 2 major consecutive steps, viz. chamber formation followed by septation. Septation is the remodeling of the heart from a single-channel peristaltic pump to a dual-channel, synchronously contracting device with 1-way valves. In the human heart, septation occurs between 4 and 7 weeks of development. Cardiac looping and chamber formation bring the contributing structures into position to engage in septation. Cardiomyocytes that participate in chamber formation do not materially contribute to septation. The (re)discovery of the role of extracardiac mesenchymal tissue in atrioventricular septation, the appreciation that the formation of the right atrioventricular connection is more than a mere rightward expansion of the atrioventricular canal, the awareness that myocardium originating from the so-called anterior heart field regresses after its function as outflow-tract sphincter ceases, and the recent finding that the myocardialized proximal portion of the outflow-tract septum becomes the supraventricular crest have all significantly enhanced our understanding of the morphogenetic processes that contribute to septation. The bifurcation of the ventricular conduction system is the landmark that separates the contribution of the atrioventricular cushions and the outflow-tract ridges to septation and that divides the muscular ventricular septum in inlet, trabecular, and outlet portions.
Wouter H Lamers; Antoon F M Moorman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Circulation research     Volume:  91     ISSN:  1524-4571     ISO Abbreviation:  Circ. Res.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-07-26     Completed Date:  2002-08-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0047103     Medline TA:  Circ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  93-103     Citation Subset:  IM    
Department of Anatomy and Embryology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
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MeSH Terms
Coronary Circulation
Heart / anatomy & histology*,  embryology*
Heart Atria / anatomy & histology,  embryology
Heart Septum / embryology*
Heart Ventricles / anatomy & histology,  embryology
Models, Cardiovascular

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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