Document Detail

Cardiac sensory receptors in Dahl salt-resistant and salt-sensitive rats.
MedLine Citation:
PMID:  3539403     Owner:  NLM     Status:  MEDLINE    
The Dahl strain of genetically salt-resistant (DR) and salt-sensitive (DS) rats affords an opportunity to explore mechanisms responsible for salt resistance and sensitivity. Dahl sensitive rats exhibit abnormalities in sympathetic neural control of the circulation and in renal sodium handling. Since cardiac baroreflexes participate in regulation of sympathetic nerve activity and sodium excretion, we have evaluated cardiac baroreflex function in DR and DS rats. This article briefly reviews evidence that cardiac sensory endings with vagal afferents are reset to a higher threshold in DS rats before elevation of arterial or cardiac filling pressures, as a result of this resetting, cardiac baroreflex inhibition of sympathetic nerve activity during volume expansion is impaired in prehypertensive DS rats, a high-sodium diet enhances the gain of cardiac baroreflex inhibition of sympathetic nerve activity in DR but not DS rats, and atrial natriuretic factor stimulates cardiac sensory receptors with vagal afferents. Taken together, these studies prompt speculation that humoral factors released during intake of a high-sodium diet may sensitize cardiac baroreflexes and thereby protect against sodium retention and hypertension. An absence of this compensatory adjustment or plasticity in cardiac baroreflex function in DS rats may predispose to salt-induced hypertension.
A L Mark; R G Victor; A Ferrari; D A Morgan; P Thorén
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulation     Volume:  75     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I137-40     Citation Subset:  AIM; IM    
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MeSH Terms
Drug Resistance
Heart Conduction System / physiology*
Neuronal Plasticity
Pressoreceptors / physiopathology
Rats, Inbred Strains / genetics*
Sensory Receptor Cells / physiopathology*
Sodium Chloride / pharmacology*
Grant Support
Reg. No./Substance:
7647-14-5/Sodium Chloride

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