Document Detail


Cardiac sensory receptors in Dahl salt-resistant and salt-sensitive rats.
MedLine Citation:
PMID:  3539403     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The Dahl strain of genetically salt-resistant (DR) and salt-sensitive (DS) rats affords an opportunity to explore mechanisms responsible for salt resistance and sensitivity. Dahl sensitive rats exhibit abnormalities in sympathetic neural control of the circulation and in renal sodium handling. Since cardiac baroreflexes participate in regulation of sympathetic nerve activity and sodium excretion, we have evaluated cardiac baroreflex function in DR and DS rats. This article briefly reviews evidence that cardiac sensory endings with vagal afferents are reset to a higher threshold in DS rats before elevation of arterial or cardiac filling pressures, as a result of this resetting, cardiac baroreflex inhibition of sympathetic nerve activity during volume expansion is impaired in prehypertensive DS rats, a high-sodium diet enhances the gain of cardiac baroreflex inhibition of sympathetic nerve activity in DR but not DS rats, and atrial natriuretic factor stimulates cardiac sensory receptors with vagal afferents. Taken together, these studies prompt speculation that humoral factors released during intake of a high-sodium diet may sensitize cardiac baroreflexes and thereby protect against sodium retention and hypertension. An absence of this compensatory adjustment or plasticity in cardiac baroreflex function in DS rats may predispose to salt-induced hypertension.
Authors:
A L Mark; R G Victor; A Ferrari; D A Morgan; P Thorén
Related Documents :
2525523 - Salt-induced hypertension in dahl salt-sensitive rats. hemodynamics and renal responses.
2737713 - How is the nacl signal transmitted in nacl-induced hypertension?
19839003 - Bitter melon protects against lipid peroxidation caused by immobilization stress in alb...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Circulation     Volume:  75     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-02-05     Completed Date:  1987-02-05     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I137-40     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Drug Resistance
Heart Conduction System / physiology*
Neuronal Plasticity
Pressoreceptors / physiopathology
Rats
Rats, Inbred Strains / genetics*
Reflex
Sensory Receptor Cells / physiopathology*
Sodium Chloride / pharmacology*
Grant Support
ID/Acronym/Agency:
HL01362/HL/NHLBI NIH HHS; HL14388/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7647-14-5/Sodium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Evidence for the existence of renin in the heart.
Next Document:  Hemodynamic benefits and prolonged survival with long-term captopril therapy in rats with myocardial...