| Cardiac sensitization testing of the halon replacement candidates trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I). | |
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MedLine Citation:
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PMID: 9598296 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trifluoroiodomethane (CF3I) and 1,1,2,2,3,3,3-heptafluoro-1-iodopropane (C3F7I) have been considered as replacement candidates for halon fire suppressants due to their excellent fire extinguishant capabilities and low ozone depletion potential compared to halon fire extinguishants in use currently. As part of the process to develop environmental and health effects criteria for halon substitutes, a cardiac sensitization test was conducted in beagle dogs. Cardiac sensitization to adrenaline is a phenomenon associated with the inhalation of a number of unsubstituted and halogenated hydrocarbons. Adrenaline was administered by intravenous injection before and during inhalation of the test substance. CF3I was administered to dogs at concentrations in air of 0.1, 0.2, 0.4 or 1% v/v. At each of 0.4 and 1.0% CF3I, the first dog exposed developed fatal ventricular fibrillation, and no further dogs were exposed at these concentrations. There was no cardiac sensitization at 0.1 or 0.2% CF3I. For the C3F7I experiment, dogs were exposed to concentrations in air of 0.1, 0.2 or 0.4% v/v. At each of 0.1 and 0.4% C3F7I, one dog responded with multifocal ventricular ectopic beats. Thus, CF3I and C3F7I are potent cardiac sensitizers in the adrenaline-challenged dog model. |
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Authors:
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D E Dodd; A Vinegar |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Drug and chemical toxicology Volume: 21 ISSN: 0148-0545 ISO Abbreviation: Drug Chem Toxicol Publication Date: 1998 May |
Date Detail:
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Created Date: 1998-08-05 Completed Date: 1998-08-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7801723 Medline TA: Drug Chem Toxicol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 137-49 Citation Subset: IM; S |
Affiliation:
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ManTech Environmental Technology, Inc., Wright-Patterson Air Force Base, OH, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Adrenergic Agonists / administration & dosage Animals Chlorofluorocarbons, Methane* Dogs Dose-Response Relationship, Drug Electrocardiography Epinephrine / administration & dosage Flame Retardants / administration & dosage, toxicity* Fluorocarbons / toxicity* Heart Rate / drug effects* Hydrocarbons, Halogenated / administration & dosage, toxicity* Injections, Intravenous Male Tachycardia, Ectopic Atrial / chemically induced Vasoconstrictor Agents / administration & dosage, toxicity* Ventricular Fibrillation / chemically induced |
| Chemical | |
Reg. No./Substance:
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0/Adrenergic Agonists; 0/Chlorofluorocarbons, Methane; 0/Flame Retardants; 0/Fluorocarbons; 0/Hydrocarbons, Halogenated; 0/Vasoconstrictor Agents; 2314-97-8/trifluoroiodomethane; 353-59-3/bromochlorodifluoromethane; 51-43-4/Epinephrine; 754-34-7/1,1,2,2,3,3,3-heptafluoro-1-iodopropane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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