| Cardiac screening of children with Down's syndrome. | |
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MedLine Citation:
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PMID: 8044724 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To establish the role of clinical and laboratory investigation of the cardiovascular system in children with Down's syndrome. DESIGN: Prospective evaluation; examiners blinded to results of laboratory studies. SETTING: Tertiary pediatric referral centre. PATIENTS: Fifty consecutive children with Down's syndrome presenting to a regional genetic centre. Children less than six weeks of age or with known heart disease were excluded. MEASURES: Following independent examinations by a geneticist and a pediatric cardiologist, an electrocardiogram (ECG) and two-dimensional and Doppler echocardiograms were carried out. RESULTS: Assessment by the geneticist yielded two false positives and five false negatives (sensitivity 67%, specificity 88%). Addition of an ECG to clinical evaluation increased the sensitivity to 80% and specificity to 90%, a rate comparable with clinical assessment by a cardiologist. No lesion requiring surgical correction was missed by this combination. CONCLUSIONS: Where expertise in pediatric echocardiography is not readily available, careful clinical assessment coupled with the interpretation of an ECG is adequate and appropriate screening of the child with Down's syndrome. |
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Authors:
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H C Rosenberg; J H Jung; H C Soltan; M D Li; G Sheridan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Canadian journal of cardiology Volume: 10 ISSN: 0828-282X ISO Abbreviation: Can J Cardiol Publication Date: 1994 Jul-Aug |
Date Detail:
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Created Date: 1994-08-30 Completed Date: 1994-08-30 Revised Date: 2008-04-09 |
Medline Journal Info:
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Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: CANADA |
Other Details:
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Languages: eng Pagination: 675-7 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Western Ontario, London. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Down Syndrome
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complications* Echocardiography Echocardiography, Doppler Electrocardiography Heart Defects, Congenital / complications, diagnosis* Humans Infant Prospective Studies Sensitivity and Specificity |
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