Document Detail

Cardiac sarcoidosis mimicking hypertrophic cardiomyopathy: clinical utility of radionuclide imaging for differential diagnosis.
MedLine Citation:
PMID:  9652326     Owner:  NLM     Status:  MEDLINE    
A 62-year-old woman with skin sarcoidosis was admitted to our hospital to ascertain whether she had cardiac involvement. Although she displayed no cardiac signs or symptoms, the electrocardiogram showed first-degree atrioventricular block, right bundle branch block with left anterior fascicular block, and giant negative T waves in the V3 lead. Echocardiography revealed marked hypertrophy localized in the basal portion of the interventricular septum (IVS) without systolic dysfunction, mimicking hypertrophic cardiomyopathy (HCM). Exercise thallium-201 myocardial imaging revealed redistribution in the anteroseptal region. Both gallium-67 (67Ga) and technetium-99m pyrophosphate (99mTc-PYP) scintigraphy revealed abnormal uptake in the myocardium. These findings disappeared after 2 months of steroid treatment. Reports of cardiac sarcoidosis mimicking HCM are rare. However, hypertrophy in the basal portion of the IVS is an important sign of early cardiac involvement in sarcoidosis. 67Ga and 99mTc-PYP scintigraphy were useful and necessary to differentiate this type of cardiac sarcoidosis from HCM.
Y Yazaki; M Isobe; M Hayasaka; M Tanaka; T Fujii; M Sekiguchi
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Japanese circulation journal     Volume:  62     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-10-09     Completed Date:  1998-10-09     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  465-8     Citation Subset:  IM    
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
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MeSH Terms
Cardiomyopathies / complications,  diagnosis*,  radionuclide imaging,  ultrasonography
Cardiomyopathy, Hypertrophic / diagnosis*,  radionuclide imaging
Diagnosis, Differential
Gallium Radioisotopes / diagnostic use
Heart Block / etiology
Middle Aged
Sarcoidosis / complications,  diagnosis*,  radionuclide imaging,  ultrasonography
Technetium Tc 99m Pyrophosphate / diagnostic use
Thallium Radioisotopes / diagnostic use
Reg. No./Substance:
0/Gallium Radioisotopes; 0/Technetium Tc 99m Pyrophosphate; 0/Thallium Radioisotopes

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