Document Detail

Cardiac saphenous vein bypass graft disease.
MedLine Citation:
PMID:  15478036     Owner:  NLM     Status:  MEDLINE    
Coronary artery bypass grafting is an effective treatment for myocardial ischaemia and is particularly important in patients with multivessel disease and diabetes. However, up to 40% of saphenous vein grafts will occlude within 10 years of surgery. The predominant mechanisms for saphenous vein graft disease are thrombosis, intimal hyperplasia, and accelerated atherosclerosis. The pathology of these changes and the role of key factors such as nitric oxide, cellular proliferation, and the role of hypercholesterolemia and hypertriglyceridaemia, are reviewed. Saphenous vein graft disease is among the first cardiovascular conditions to show significant benefit from gene therapy and promises to show remarkable developments in the near future.
G T Lau; H C Lowe; L Kritharides
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Seminars in vascular medicine     Volume:  4     ISSN:  1528-9648     ISO Abbreviation:  Semin Vasc Med     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-10-12     Completed Date:  2005-02-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100940307     Medline TA:  Semin Vasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-9     Citation Subset:  IM    
Department of Cardiology, Concord Repatriation General Hospital, Hospital Rd, Concord, NSW 2139, Australia.
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MeSH Terms
Cell Proliferation
Coronary Artery Bypass*
Diabetic Angiopathies / physiopathology
Graft Occlusion, Vascular / pathology,  physiopathology*
Hyperlipidemias / physiopathology
Nitric Oxide / physiology
Risk Factors
Saphenous Vein / pathology,  transplantation*
Vascular Endothelial Growth Factor A / therapeutic use
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A; 10102-43-9/Nitric Oxide

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