Document Detail


Cardiac rupture after myocardial infarction: new insights from murine models.
MedLine Citation:
PMID:  19829180     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac rupture after a myocardial infarction is an uncommon event with devastating consequences. Although the clinical features of rupture have been described, the genetic and molecular influences on this outcome in patients are less certain. In mice, at least 17 genetic models have been developed that enhance or suppress the likelihood of rupture postmyocardial infarction. The purpose of this review is to describe these recent advances, recognizing that nearly all of the information has been obtained from mouse models of free wall rupture. Although it is probable that the same genetic determinants apply to septal and papillary muscle rupture, the possibility remains that there are unique modulators of risk for rupture at differing anatomic sites within the heart. It is likely that the candidate genes also influence rupture in humans, although this conclusion must be confirmed. The mouse models will be helpful to direct future proteomic and genomic studies in patients and may already suggest certain fundamental pathways. For example, the essential role of collagen production and stabilization postmyocardial infarction may direct therapies to enhance collagen cross-linking and limit its degradation as a strategy to reduce rates of rupture and enhance myocardial healing.
Authors:
David C Sane; Willis Scott Mozingo; Richard C Becker
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Cardiology in review     Volume:  17     ISSN:  1538-4683     ISO Abbreviation:  Cardiol Rev     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-10-15     Completed Date:  2010-01-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9304686     Medline TA:  Cardiol Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  293-9     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Section on Cardiology, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. dsane@wfubmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Collagen / genetics,  metabolism
Heart Rupture, Post-Infarction / genetics*,  metabolism
Humans
Mice
Models, Animal*
Models, Genetic*
Proteomics
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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