| Cardiac rhythm disturbances and ST-segment depression episodes in patients with obstructive sleep apnea-hypopnea syndrome and its mechanisms. | |
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MedLine Citation:
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PMID: 15653957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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STUDY OBJECTIVES: To compare the frequency of daytime and nocturnal cardiac arrhythmias and ST-segment depression episodes among patients with obstructive sleep apnea-hypopnea syndrome (OSAHS), snoring subjects, and healthy subjects, and to analyze the relationship between the cardiac disturbances, sleep characteristics, and sympathetic tone in patients with OSAHS. PATIENTS AND INTERVENTIONS: Twenty-one consecutive patients with OSAHS, 12 snorers without hypersomnolence, and 15 healthy subjects were selected. Polysomnography, 24-h Holter ECG recording, and urinary catecholamine determination were simultaneously performed on all subjects. RESULTS: Patients with OSAHS had more daytime and nocturnal episodes of sinus and supraventricular arrhythmias and couplets than the snoring and control groups. Moreover, nocturnal ST-segment depression episodes were more frequent in the OSAHS group than in control subjects (0.565 +/- 0.826/h vs 0 +/- 0/h [mean +/- SD]). In patients with OSAHS, arousal index and daytime epinephrine levels were related to daytime and nocturnal ST-segment depression episodes, whereas minimum arterial oxygen saturation was related to nocturnal sinus bradycardia and supraventricular tachycardia. Epinephrine and norepinephrine urinary concentrations correlated with sinus and supraventricular arrhythmias. CONCLUSIONS: Patients with OSAHS have a higher frequency of cardiac rhythm disturbances and ST-segment depression episodes than snoring and control subjects. Moreover, ST-segment changes are related to sympathetic tone and sleep fragmentation, whereas most of the rhythm disturbances in patients with OSAHS are associated with sleep fragmentation, nocturnal hypoxemia, and sympathetic tone. |
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Authors:
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Alberto Alonso-Fernández; Francisco García-Río; Miguel A Racionero; José M Pino; Fernando Ortuño; Isabel Martínez; José Villamor |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chest Volume: 127 ISSN: 0012-3692 ISO Abbreviation: Chest Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-17 Completed Date: 2005-02-22 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: United States |
Other Details:
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Languages: eng Pagination: 15-22 Citation Subset: AIM; IM |
Affiliation:
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Servicios de Neumología, Hospital Universitario La Paz, Spain. aaf_97@hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Arousal Arrhythmia, Sinus / epidemiology Arrhythmias, Cardiac / blood, epidemiology* Blood Pressure Catecholamines / blood Electrocardiography, Ambulatory Female Humans Male Middle Aged Polysomnography Sleep Apnea, Obstructive / blood, epidemiology* Snoring / epidemiology* |
| Chemical | |
Reg. No./Substance:
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0/Catecholamines |
| Comments/Corrections | |
Comment In:
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Chest. 2005 Jan;127(1):1-3
[PMID:
15653950
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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