Document Detail


Cardiac rhabdomyomas and their association with tuberous sclerosis.
MedLine Citation:
PMID:  8466239     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A search for children presenting with signs or symptoms of cardiac rhabdomyomas was made through members of the paediatric section of the British Cardiac Society in order to establish their birth incidence, presenting features, clinical course, and the frequency of a concurrent diagnosis of tuberous sclerosis. Fifteen children were identified and 12 had tuberous sclerosis (80%). Heart failure was the presentation in six, five of whom died; six presented because of a murmur and three because of arrhythmias. The prevalence of echocardiographic evidence of cardiac rhabdomyomas in a population of patients with tuberous sclerosis was established. Twenty individuals had echocardiography and eight had echodensities consistent with cardiac rhabdomyomas. It is concluded that the minimum birth incidence for children presenting because of the effects of cardiac rhabdomyomas is 1/326,000 and a minimum of 80% have tuberous sclerosis. In a population of patients with tuberous sclerosis a minimum of 60% under 18 years have cardiac rhabdomyomas.
Authors:
D W Webb; R D Thomas; J P Osborne
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of disease in childhood     Volume:  68     ISSN:  1468-2044     ISO Abbreviation:  Arch. Dis. Child.     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-05-04     Completed Date:  1993-05-04     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372434     Medline TA:  Arch Dis Child     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  367-70     Citation Subset:  AIM; IM    
Affiliation:
Bath Unit for Research into Paediatrics, Royal United Hospital, Combe Park.
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MeSH Terms
Descriptor/Qualifier:
Echocardiography
Female
Heart Neoplasms / complications*,  pathology
Humans
Infant
Infant, Newborn
Male
Myocardium / pathology
Rhabdomyosarcoma / complications*,  pathology
Tuberous Sclerosis / complications*
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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