| Cardiac resynchronization therapy may benefit patients with left ventricular ejection fraction >35%: a PROSPECT trial substudy. | |
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MedLine Citation:
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PMID: 20150328 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: Cardiac resynchronization therapy (CRT) is currently limited to those with left ventricular ejection fraction (LVEF) < or =35%. To evaluate whether patients with LVEF >35% might benefit from CRT, we performed a retrospective analysis of the predictors of response to CRT (PROSPECT) database. METHODS AND RESULTS: PROSPECT was a prospective, multicentre study that enrolled CRT patients based on enrolling centre-evaluated LVEF <35%, but all echocardiograms were subsequently analysed by a core laboratory. Patients with core laboratory-measured LVEF >35% (OVER35) were compared with those whose LVEF was <35% (UNDER35). Clinical composite score (CCS) and change in LV end systolic volume (LVESV) were analysed from baseline to 6-month follow-up. Of 361 patients, 86 (24%) had LVEF >35%. At entry, OVER35 had smaller LV volumes, shorter QRS duration, shorter 6-min walk distance, and were more likely to have ischaemic aetiology than UNDER35. Outcomes were comparable between the groups, with 62.8% of OVER35 improved in CCS (70.2% in UNDER35) and 50.8% of OVER35 improved in LVESV (57.8% in UNDER35). CONCLUSION: Patients with LVEF >35%, New York heart association functional Class III-IV status, and QRS >130 ms appear to derive clinical and structural benefit from CRT. As CRT may offer a valuable option for these patients, this hypothesis should be formally tested in a prospective, randomized multicentre trial. |
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Authors:
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Eugene S Chung; Rodolphe P Katra; Stefano Ghio; Jeroen Bax; Bart Gerritse; Kathryn Hilpisch; Brett J Peterson; David S Feldman; William T Abraham |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-11 |
Journal Detail:
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Title: European journal of heart failure Volume: 12 ISSN: 1879-0844 ISO Abbreviation: Eur. J. Heart Fail. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-25 Completed Date: 2010-08-20 Revised Date: 2011-06-08 |
Medline Journal Info:
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Nlm Unique ID: 100887595 Medline TA: Eur J Heart Fail Country: Netherlands |
Other Details:
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Languages: eng Pagination: 581-7 Citation Subset: IM |
Affiliation:
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The Christ Hospital and The Ohio Heart and Vascular Center, 2123 Auburn Avenue, Ste 100, Cincinnati, OH, USA. chunge@ohioheart.org |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cardiac Pacing, Artificial* Female Heart Failure / physiopathology, therapy* Humans Male Middle Aged Retrospective Studies Stroke Volume |
| Comments/Corrections | |
Comment In:
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Eur J Heart Fail. 2010 Jun;12(6):527-9
[PMID:
20498266
]
Eur J Heart Fail. 2010 Oct;12(10):1140-1; author reply 1141 [PMID: 20810474 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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