| Cardiac resynchronization therapy and its potential proarrhythmic effect. | |
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MedLine Citation:
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PMID: 17823906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cardiac resynchronization therapy (CRT) has become an established adjunctive treatment to optimal pharmacologic therapy in patients with advanced chronic heart failure (CHF), diminished left ventricular (LV) function and intraventricular conduction delay. Although CRT has been shown to improve ventricular hemodynamics, quality of life and exercise capacity, there is some evidence that it may rarely potentiate ventricular arrhythmias. As CRT is considered for an expanded population of CHF patients, and left-sided pacing is considered as an option for pacemaker-indicated patients (potentially without defibrillator backup), the effect of these pacing modalities on the incidence of ventricular tachyarrhythmia must be systematically studied and mechanistically understood. Strategies to prospectively predict the proarrhythmic potential of LV epicardial pacing need to be developed, and therapy accordingly individualized. This review attempts to summarize the current information on proarrhythmia in resynchronization therapy. |
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Authors:
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Indranill Basu Ray; Lahn Fendelander; Jagmeet P Singh |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Clinical cardiology Volume: 30 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 2007 Oct |
Date Detail:
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Created Date: 2007-10-17 Completed Date: 2008-01-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 498-502 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2007 Wiley Periodicals, Inc. |
Affiliation:
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Harvard Thorndike Electrophysiology Institute, Department of Medicine, Beth Israel Deaconess Medical Center, Guidant Corporation, St. Paul, Minnesota, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cardiac Pacing, Artificial
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adverse effects*,
mortality Death, Sudden, Cardiac / prevention & control Defibrillators, Implantable Heart Failure / therapy* Humans Risk Factors Tachycardia, Ventricular / etiology*, mortality Ventricular Dysfunction, Left / therapy* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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