Document Detail


Cardiac resynchronization therapy in heart failure.
MedLine Citation:
PMID:  15875517     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac resynchronization therapy (CRT) is a new therapeutic approach for a selected group of patients with symptomatic heart failure (NYHA functional class III-IV) despite optimal medical therapy, due to dilated cardiomyopathy of any etiology (left ventricular ejection fraction < or = 35% and left ventricular end-diastolic diameter > or = 55 mm), who present with electromechanical dyssynchrony (QRS > or = 130 ms). Safety and effectiveness of CRT have been demonstrated by several clinical trials, with patients achieving significant improvement in both clinical symptoms as well as functional status and exercise capacity. Furthermore, CRT has reduced morbidity of heart failure patients, while its impact in improving survival still remains to be clarified. Whether or not heart failure patients candidate to CRT should receive a defibrillator back-up remains debatable, although growing evidence is pointing to extensive use of a defibrillator in such a population.
Authors:
Angelo Auricchio; Cecilia Fantoni
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Italian heart journal : official journal of the Italian Federation of Cardiology     Volume:  6     ISSN:  1129-471X     ISO Abbreviation:  Ital Heart J     Publication Date:  2005 Mar 
Date Detail:
Created Date:  2005-05-06     Completed Date:  2005-07-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100909716     Medline TA:  Ital Heart J     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  256-60     Citation Subset:  IM    
Affiliation:
Division of Cardiology, University Hospital, Magdeburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Cardiac Pacing, Artificial
Electrodes, Implanted
Heart Failure / complications,  therapy*
Humans
Ventricular Dysfunction, Left / etiology,  therapy*

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