Document Detail

Cardiac resynchronization therapy for the causal treatment of heart failure with preserved ejection fraction: insight from a pressure-volume loop analysis.
MedLine Citation:
PMID:  20436036     Owner:  NLM     Status:  MEDLINE    
This case describes a middle-aged patient with normal ejection fraction (64%) and significant dyspnoea which could not be explained by results from routine examinations. A pressure-volume loop analysis revealed severe left ventricular (LV) dyssynchrony to be the underlying mechanism of heart failure. The patient underwent implantation of a biventricular pacemaker. Cardiac resynchronization therapy (CRT) was associated with an immediate reduction in LV dyssynchrony from 32 to 13%, decrease in LV end-diastolic pressure from 19 to 8 mmHg, and increased exercise tolerance during follow-up. Thus, CRT may be considered a causal therapy in selected patients with heart failure and preserved ejection fraction.
Martin Penicka; Viktor Kocka; Dalibor Herman; Helena Trakalova; Martin Herold
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-30
Journal Detail:
Title:  European journal of heart failure     Volume:  12     ISSN:  1879-0844     ISO Abbreviation:  Eur. J. Heart Fail.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-25     Completed Date:  2010-08-20     Revised Date:  2011-06-08    
Medline Journal Info:
Nlm Unique ID:  100887595     Medline TA:  Eur J Heart Fail     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  634-6     Citation Subset:  IM    
Cardiovascular Center Aalst, Moorselbaan 164, Aalst, Belgium.
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MeSH Terms
Bundle-Branch Block / therapy*
Cardiac Pacing, Artificial*
Heart Failure / etiology,  physiopathology*,  therapy*
Middle Aged
Stroke Volume
Ventricular Dysfunction, Left / therapy*
Comment In:
Eur J Heart Fail. 2010 Jun;12(6):527-9   [PMID:  20498266 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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