Document Detail

Cardiac resynchronization therapy for adult congenital heart disease patients with a systemic right ventricle: analysis of feasibility and review of early experience.
MedLine Citation:
PMID:  16627452     Owner:  NLM     Status:  MEDLINE    
AIMS: Patients with a systemic right ventricle (RV) frequently develop heart failure and may benefit from cardiac resynchronization therapy (CRT). We aimed to assess the proportion of unselected patients with a systemic RV eligible for CRT and to review available data on the effect of CRT in congenital heart disease patients. METHODS AND RESULTS: Adhering to criteria derived from landmark CRT trials, we determined the eligibility of patients with a systemic RV for CRT. Seventy-five transposition of the great arteries (TGA) patients (age 29.5+/-10.2 years) and 49 patients with congenitally corrected (cc) TGA (age 36.2+/-12.8 years) were studied. Full criteria for CRT were met in 4.0% of the TGA patients and 4.1% of the ccTGA patients. Including New York Heart Association class 2 patients, 9.3% of TGA and 6.1% of ccTGA patients were eligible for CRT. CONCLUSION: Four to 9% of unselected patients with a systemic RV appear to be potential candidates for CRT. Although large clinical studies are currently lacking, available data consistently demonstrate that CRT improves haemodynamics in congenital heart disease patients and warrants further investigation.
Gerhard-Paul Diller; Darlington Okonko; Anselm Uebing; Siew Yen Ho; Michael A Gatzoulis
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-21
Journal Detail:
Title:  Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology     Volume:  8     ISSN:  1099-5129     ISO Abbreviation:  Europace     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-09-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100883649     Medline TA:  Europace     Country:  England    
Other Details:
Languages:  eng     Pagination:  267-72     Citation Subset:  IM    
Adult Congenital Heart Programme, Royal Brompton Hospital, Sydney Street, SW3 6NP London, UK.
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MeSH Terms
Cardiac Pacing, Artificial*
Chi-Square Distribution
Retrospective Studies
Statistics, Nonparametric
Transposition of Great Vessels / physiopathology*,  surgery,  therapy*
Ventricular Dysfunction, Right / congenital,  physiopathology*,  therapy*

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