Document Detail


Cardiac repolarization instability during normal postnatal development.
MedLine Citation:
PMID:  18804789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Long QT syndrome is a disease characterized by abnormal lengthening of the QT interval and by sudden cardiac death. It is a disease of development, with the incidence of a sudden event increasing during childhood. Repolarization instability during postnatal development could make the substrate susceptible to a fatal arrhythmia. Dynamic changes in repolarization that occur on a beat-to-beat basis, known as alternans, are a hallmark of electrical instability. T-wave alternans (TWA) in the electrocardiogram correlates with arrhythmia risk and long-term survival in adults. We determined TWA properties longitudinally in vivo in 7 propofol-sedated New Zealand white rabbits using transesophageal pacing weekly from 2 to 10 weeks of age. Furthermore, TWA induction after the onset of rapid pacing was characterized in vitro in 6 infant (2 weeks) and 6 adolescent (7 weeks) isolated, arterially perfused rabbit hearts. In vivo, TWA amplitude was maximum at 2 weeks and declined with age. Isoproterenol increased TWA at 8 weeks (adolescence). In vitro, large-amplitude TWA was induced with rapid pacing in both infant and adolescents but decreased to low, steady-state levels in infants. We conclude that TWA properties are age dependent in rabbit. Significant TWA is induced in rabbit at the onset of rapid pacing.
Authors:
Salim F Idriss; Jamie A Bell
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2008-09-19
Journal Detail:
Title:  Journal of electrocardiology     Volume:  41     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:    2008 Nov-Dec
Date Detail:
Created Date:  2008-10-28     Completed Date:  2009-01-09     Revised Date:  2013-01-03    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  474-9     Citation Subset:  IM    
Affiliation:
Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA. salim.idriss@duke.edu
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MeSH Terms
Descriptor/Qualifier:
Aging*
Animals
Arrhythmias, Cardiac / diagnosis*,  physiopathology*
Heart Conduction System / physiopathology*
Rabbits
Grant Support
ID/Acronym/Agency:
K12 HD043494/HD/NICHD NIH HHS; K12 HD043494-04/HD/NICHD NIH HHS; K12-HD-43494/HD/NICHD NIH HHS; R01 HL072831-02S1/HL/NHLBI NIH HHS; R01-HL-72831/HL/NHLBI NIH HHS
Comments/Corrections
Comment In:
J Electrocardiol. 2009 May-Jun;42(3):300-1   [PMID:  19070869 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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