| Cardiac repolarization instability during normal postnatal development. | |
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MedLine Citation:
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PMID: 18804789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Long QT syndrome is a disease characterized by abnormal lengthening of the QT interval and by sudden cardiac death. It is a disease of development, with the incidence of a sudden event increasing during childhood. Repolarization instability during postnatal development could make the substrate susceptible to a fatal arrhythmia. Dynamic changes in repolarization that occur on a beat-to-beat basis, known as alternans, are a hallmark of electrical instability. T-wave alternans (TWA) in the electrocardiogram correlates with arrhythmia risk and long-term survival in adults. We determined TWA properties longitudinally in vivo in 7 propofol-sedated New Zealand white rabbits using transesophageal pacing weekly from 2 to 10 weeks of age. Furthermore, TWA induction after the onset of rapid pacing was characterized in vitro in 6 infant (2 weeks) and 6 adolescent (7 weeks) isolated, arterially perfused rabbit hearts. In vivo, TWA amplitude was maximum at 2 weeks and declined with age. Isoproterenol increased TWA at 8 weeks (adolescence). In vitro, large-amplitude TWA was induced with rapid pacing in both infant and adolescents but decreased to low, steady-state levels in infants. We conclude that TWA properties are age dependent in rabbit. Significant TWA is induced in rabbit at the onset of rapid pacing. |
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Authors:
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Salim F Idriss; Jamie A Bell |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. Date: 2008-09-19 |
Journal Detail:
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Title: Journal of electrocardiology Volume: 41 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-10-28 Completed Date: 2009-01-09 Revised Date: 2013-01-03 |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 474-9 Citation Subset: IM |
Affiliation:
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Pediatric Cardiology, Duke University Medical Center, Durham, NC 27710, USA. salim.idriss@duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging* Animals Arrhythmias, Cardiac / diagnosis*, physiopathology* Heart Conduction System / physiopathology* Rabbits |
| Grant Support | |
ID/Acronym/Agency:
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K12 HD043494/HD/NICHD NIH HHS; K12 HD043494-04/HD/NICHD NIH HHS; K12-HD-43494/HD/NICHD NIH HHS; R01 HL072831-02S1/HL/NHLBI NIH HHS; R01-HL-72831/HL/NHLBI NIH HHS |
| Comments/Corrections | |
Comment In:
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J Electrocardiol. 2009 May-Jun;42(3):300-1
[PMID:
19070869
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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