Document Detail


Cardiac repair in a porcine model of acute myocardial infarction with human induced pluripotent stem cell-derived cardiovascular cells.
MedLine Citation:
PMID:  25479750     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Human induced pluripotent stem cells (hiPSCs) hold promise for myocardial repair following injury, but preclinical studies in large animal models are required to determine optimal cell preparation and delivery strategies to maximize functional benefits and to evaluate safety. Here, we utilized a porcine model of acute myocardial infarction (MI) to investigate the functional impact of intramyocardial transplantation of hiPSC-derived cardiomyocytes, endothelial cells, and smooth muscle cells, in combination with a 3D fibrin patch loaded with insulin growth factor (IGF)-encapsulated microspheres. hiPSC-derived cardiomyocytes integrated into host myocardium and generated organized sarcomeric structures, and endothelial and smooth muscle cells contributed to host vasculature. Trilineage cell transplantation significantly improved left ventricular function, myocardial metabolism, and arteriole density, while reducing infarct size, ventricular wall stress, and apoptosis without inducing ventricular arrhythmias. These findings in a large animal MI model highlight the potential of utilizing hiPSC-derived cells for cardiac repair.
Authors:
Lei Ye; Ying-Hua Chang; Qiang Xiong; Pengyuan Zhang; Liying Zhang; Porur Somasundaram; Mike Lepley; Cory Swingen; Liping Su; Jacqueline S Wendel; Jing Guo; Albert Jang; Daniel Rosenbush; Lucas Greder; James R Dutton; Jianhua Zhang; Timothy J Kamp; Dan S Kaufman; Ying Ge; Jianyi Zhang
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell stem cell     Volume:  15     ISSN:  1875-9777     ISO Abbreviation:  Cell Stem Cell     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101311472     Medline TA:  Cell Stem Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  750-61     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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