Document Detail

Cardiac remodeling in patients with primary aldosteronism.
MedLine Citation:
PMID:  19564719     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the morpho-functional changes of the myocardium in patients with primary aldosteronism (PA). DESIGN: An observational study in a university referral center for blood pressure diseases. PATIENTS: Twenty- three patients with PA, 24 patients with essential hypertension (EH), and 15 normotensive controls (C) underwent conventional echocardiography with integrated backscatter (IBS) and tissue Doppler imaging (TDI) analysis. The corrected IBS (C-IBS) values and the systo-diastolic variation of IBS (CV-IBS) were performed at both interventricular septum and the posterior wall levels. TDI myocardial systolic (Sm), early diastolic (Em), and late diastolic (Am) velocities of both left ventricular walls were also determined. RESULTS: In PA patients, septal and posterior wall CV-IBS were significantly lower than C (p<0.0001) and EH patients (p<0.001). In EH, CV-IBS was significantly lower than C (p<0.001). Patients with PA exhibited lower Sm, lower Em, and higher Am, and a subsequently reduced Em/Am ratio than C (p<0.001 for all) and EH (p<0.01 for all) at interventricular septum and lateral wall levels. In the latter, Sm, Em, and Em/Am ratio were lower and Am was higher than C (p<0.001 for all). In PA and EH patients, CV-IBS at both septum (r=-0.66, p<0.001) and posterior wall levels (r=-0.67, p<0.001) and Sm peak of both septum (r=-0.52, p<0.001) and lateral wall (r=-0.55, p<0.001) were inversely related to plasma aldosterone. CONCLUSIONS: Patients with PA showed myocardial wall remodeling characterized by increased myocardial fibrosis and early left ventricular systodiastolic function abnormalities.
F Galetta; G Bernini; F Franzoni; A Bacca; I Fivizzani; L Tocchini; M Bernini; P Fallahi; A Antonelli; G Santoro
Related Documents :
433749 - Limitations of the cardiokymograph for assessing left ventricular wall motion.
8048779 - Effects of intracoronary infusion of adenosine on cumulative deterioration of regional ...
862169 - Correlation of coronary arteriograms and left ventriculograms with postmortem studies.
3620249 - Global and regional right ventricular function after acute myocardial infarction: depen...
7555159 - Changes in wall motion in patients treated for unstable angina. a suggestion of the stu...
2086439 - Fetal echocardiography--norms for m-mode measurements.
16936699 - Regulation of cardiac hypertrophy by intracellular signalling pathways.
1472659 - Qrs complex changes in the v5 ecg lead during cardiac surgery.
23184309 - Interrelation between myocardial oxidative metabolism and diastolic function in patient...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  32     ISSN:  1720-8386     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  739-45     Citation Subset:  IM    
Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Heart / physiopathology*
Hyperaldosteronism / physiopathology*,  ultrasonography
Hypertension / physiopathology,  ultrasonography
Middle Aged

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Next Document:  Growth Hormone Response To Physical Exercise in Growing Patients with Classic Congenital Adrenal Hyp...