Document Detail


Cardiac remodeling in patients with systemic sclerosis with no signs or symptoms of heart failure: an endomyocardial biopsy study.
MedLine Citation:
PMID:  13680552     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Systemic sclerosis (SSc) is a disease characterized by the fibrosis of the skin and internal organs. The nature and functional significance of myocardial damage is controversial. Systematic endomyocardial biopsy in this disease has not yet been performed. METHODS: The hypothesis that increased myocardial fibrous tissue deposition occurs in patients with systemic sclerosis with no signs or symptoms of heart failure and normal left systolic ventricle function was tested in 16 SSc patients and 10 controls. Endomyocardial biopsy specimens were obtained from the right ventricular septum in SSc patients. Myocardial specimens were obtained from the same area in controls. Masson's trichrome staining was used for collagen fiber identification. Interstitial (ICVF) and perivascular collagen volume fraction (PCVF) was quantified by videomorphometry. There was a significant increase in the ICVF in patients with SSc compared with the controls, in spite of normal systolic left ventricular function. However, it was not observed in the PCVF. CONCLUSIONS: It is possible to identify cardiac remodeling, characterized by myocardial fibrosis deposits, particularly within the interstitium in SSc patients before the any signs or symptoms of heart failure appear.
Authors:
Fábio Fernandes; Félix José Alvarez Ramires; Edmundo Arteaga; Barbara Maria Ianni; Eloisa Silva Dutra Oliveira Bonfá; Charles Mady
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  9     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-18     Completed Date:  2004-03-19     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  311-7     Citation Subset:  IM    
Affiliation:
Heart Institute, University of São Paulo Medical School, São Paulo, SP, Brazil.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aortic Valve / pathology,  ultrasonography
Biopsy
Brazil
Collagen / metabolism
Echocardiography, Doppler
Endocardium / metabolism,  pathology,  ultrasonography
Endomyocardial Fibrosis / diagnosis,  physiopathology
Female
Heart Failure / diagnosis,  physiopathology*
Heart Ventricles / metabolism,  physiopathology,  ultrasonography
Humans
Male
Middle Aged
Mitral Valve / pathology,  ultrasonography
Myocardium / metabolism,  pathology
Scleroderma, Systemic / diagnosis,  physiopathology*
Systole / physiology
Ventricular Function, Left / physiology
Ventricular Remodeling / physiology*
Chemical
Reg. No./Substance:
9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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