| Cardiac remodeling in patients with systemic sclerosis with no signs or symptoms of heart failure: an endomyocardial biopsy study. | |
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MedLine Citation:
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PMID: 13680552 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Systemic sclerosis (SSc) is a disease characterized by the fibrosis of the skin and internal organs. The nature and functional significance of myocardial damage is controversial. Systematic endomyocardial biopsy in this disease has not yet been performed. METHODS: The hypothesis that increased myocardial fibrous tissue deposition occurs in patients with systemic sclerosis with no signs or symptoms of heart failure and normal left systolic ventricle function was tested in 16 SSc patients and 10 controls. Endomyocardial biopsy specimens were obtained from the right ventricular septum in SSc patients. Myocardial specimens were obtained from the same area in controls. Masson's trichrome staining was used for collagen fiber identification. Interstitial (ICVF) and perivascular collagen volume fraction (PCVF) was quantified by videomorphometry. There was a significant increase in the ICVF in patients with SSc compared with the controls, in spite of normal systolic left ventricular function. However, it was not observed in the PCVF. CONCLUSIONS: It is possible to identify cardiac remodeling, characterized by myocardial fibrosis deposits, particularly within the interstitium in SSc patients before the any signs or symptoms of heart failure appear. |
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Authors:
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Fábio Fernandes; Félix José Alvarez Ramires; Edmundo Arteaga; Barbara Maria Ianni; Eloisa Silva Dutra Oliveira Bonfá; Charles Mady |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of cardiac failure Volume: 9 ISSN: 1071-9164 ISO Abbreviation: J. Card. Fail. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-18 Completed Date: 2004-03-19 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9442138 Medline TA: J Card Fail Country: United States |
Other Details:
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Languages: eng Pagination: 311-7 Citation Subset: IM |
Affiliation:
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Heart Institute, University of São Paulo Medical School, São Paulo, SP, Brazil. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aortic Valve / pathology, ultrasonography Biopsy Brazil Collagen / metabolism Echocardiography, Doppler Endocardium / metabolism, pathology, ultrasonography Endomyocardial Fibrosis / diagnosis, physiopathology Female Heart Failure / diagnosis, physiopathology* Heart Ventricles / metabolism, physiopathology, ultrasonography Humans Male Middle Aged Mitral Valve / pathology, ultrasonography Myocardium / metabolism, pathology Scleroderma, Systemic / diagnosis, physiopathology* Systole / physiology Ventricular Function, Left / physiology Ventricular Remodeling / physiology* |
| Chemical | |
Reg. No./Substance:
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9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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