Document Detail

Cardiac remodeling and failure after myocardial infarction.
MedLine Citation:
PMID:  7621314     Owner:  NLM     Status:  MEDLINE    
Acute myocardial infarction, particularly when it produces large transmural infarcts, can initiate complex changes in the structural and functional architecture of both infarcted and non-infarcted regions of the left ventricle, known as ventricular remodelling; these changes can profoundly affect left ventricular function and, consequently, clinical outcome and prognosis. Ventricular remodelling is a dynamic process with regional and global effects on wall thickness and composition and on chamber size, shape and function; it can include infarct extension, infarct expansion, regional and global distortion and ventricular dilatation. A systematic strategy for the [primary] prevention of cardiac remodeling should probably be applied as early as possible to all patients suffering acute myocardial infarction. A [secondary] prevention strategy should focus on the early identification and treatment of subsets of patients with evidence of cardiac remodeling, because later treatments have already been shown to be beneficial. Cardiologists must choose the strategy most appropriate for each individual patient.
G L Nicolosi
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of cardiovascular risk     Volume:  1     ISSN:  1350-6277     ISO Abbreviation:  J Cardiovasc Risk     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-08-29     Completed Date:  1995-08-29     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9436980     Medline TA:  J Cardiovasc Risk     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  310-3     Citation Subset:  IM    
Department of Cardiology, A.R.C., Ospedale Civile, Pordenone, Italy.
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MeSH Terms
Cardiac Output, Low / etiology*,  physiopathology,  prevention & control
Heart Ventricles / pathology,  physiopathology
Myocardial Infarction / complications*,  pathology,  physiopathology
Ventricular Dysfunction, Left / etiology*,  physiopathology,  prevention & control
Ventricular Function, Left*

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