Document Detail


Cardiac regenerative capacity and mechanisms.
MedLine Citation:
PMID:  23057748     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heart holds the monumental yet monotonous task of maintaining circulation. Although cardiac function is critical to other organs and to life itself, mammals are not equipped with significant natural capacity to replace heart muscle that has been lost by injury. This deficiency plays a role in leaving millions worldwide vulnerable to heart failure each year. By contrast, certain other vertebrate species such as zebrafish are strikingly good at heart regeneration. A cellular and molecular understanding of endogenous regenerative mechanisms and advances in methodology to transplant cells together project a future in which cardiac muscle regeneration can be therapeutically stimulated in injured human hearts. This review focuses on what has been discovered recently about cardiac regenerative capacity and how natural mechanisms of heart regeneration in model systems are stimulated and maintained.
Authors:
Kazu Kikuchi; Kenneth D Poss
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Annual review of cell and developmental biology     Volume:  28     ISSN:  1530-8995     ISO Abbreviation:  Annu. Rev. Cell Dev. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-03-04     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9600627     Medline TA:  Annu Rev Cell Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  719-41     Citation Subset:  IM    
Affiliation:
Developmental and Stem Cell Biology Division, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales 2010, Australia. k.kikuchi@victorchang.edu.au
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Differentiation
Cell Proliferation
Disease Models, Animal
Heart / physiopathology*
Humans
Myocardial Infarction / pathology,  physiopathology
Myocytes, Cardiac / physiology
Regeneration*
Regenerative Medicine
Stem Cells / physiology
Grant Support
ID/Acronym/Agency:
R01 HL081674/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Comments/Corrections

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