Document Detail


Cardiac regeneration.
MedLine Citation:
PMID:  22449849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact. Major research efforts are attempting to change this through advances in cell therapy or activating endogenous regenerative mechanisms that exist only early in life. In contrast with mammals, lower vertebrates like zebrafish demonstrate an impressive natural capacity for cardiac regeneration throughout life. This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation.
Authors:
Wen-Yee Choi; Kenneth D Poss
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current topics in developmental biology     Volume:  100     ISSN:  1557-8933     ISO Abbreviation:  Curr. Top. Dev. Biol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-03-27     Completed Date:  2012-06-25     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  0163114     Medline TA:  Curr Top Dev Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  319-44     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Disease Models, Animal
Heart / physiology*
Heart Injuries / metabolism,  therapy
Humans
Regeneration*
Tissue Therapy
Grant Support
ID/Acronym/Agency:
R01 HL081674/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute
Comments/Corrections

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