| Cardiac regeneration. | |
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MedLine Citation:
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PMID: 22449849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The heart is a pump that is comprised of cardiac myocytes and other cell types and whose proper function is critical to quality of life. The ability to trigger regeneration of heart muscle following injury eludes adult mammals, a deficiency of great clinical impact. Major research efforts are attempting to change this through advances in cell therapy or activating endogenous regenerative mechanisms that exist only early in life. In contrast with mammals, lower vertebrates like zebrafish demonstrate an impressive natural capacity for cardiac regeneration throughout life. This review will cover recent progress in the field of heart regeneration with a focus on endogenous regenerative capacity and its potential manipulation. |
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Authors:
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Wen-Yee Choi; Kenneth D Poss |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current topics in developmental biology Volume: 100 ISSN: 1557-8933 ISO Abbreviation: Curr. Top. Dev. Biol. Publication Date: 2012 |
Date Detail:
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Created Date: 2012-03-27 Completed Date: 2012-06-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0163114 Medline TA: Curr Top Dev Biol Country: United States |
Other Details:
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Languages: eng Pagination: 319-44 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Cell Biology, Howard Hughes Medical Institute, Duke University Medical Center, Durham, North Carolina, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Disease Models, Animal Heart / physiology* Heart Injuries / metabolism, therapy Humans Regeneration* Tissue Therapy |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL081674/HL/NHLBI NIH HHS; //Howard Hughes Medical Institute; //Howard Hughes Medical Institute |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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