| Cardiac regeneration: repopulating the heart. | |
| | |
MedLine Citation:
|
PMID: 16460265 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided that the newly formed myocytes structurally and functionally integrate in the preexisting myocardium. A number of approaches have been utilized to effect regenerative growth of the myocardium in experimental animals. These include interventions aimed at enhancing the ability of cardiomyocytes to proliferate in response to cardiac injury, as well as transplantation of cardiomyocytes or myogenic stem cells into diseased hearts. Here we review efforts to induce myocardial regeneration. We also provide a critical review of techniques currently used to assess cardiac regeneration and functional integration of de novo cardiomyocytes. |
| | |
Authors:
|
Michael Rubart; Loren J Field |
Related Documents
:
|
2940815 - Electron microscopic autoradiographic study of heart muscle calcium in experimental car... 20863415 - Intracoronary delivery of bone-marrow-derived stem cells. 17628855 - Mesothelial cell transplantation in myocardial infarction. 20347795 - Intracoronary infusion of cd133+ endothelial progenitor cells improves heart function a... 1751115 - A sophisticated electromechanical ventricular simulator for ventricular assist system t... 23092255 - Stem cell therapy for the treatment of acute myocardial infarction and chronic ischemic... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Review |
Journal Detail:
|
Title: Annual review of physiology Volume: 68 ISSN: 0066-4278 ISO Abbreviation: Annu. Rev. Physiol. Publication Date: 2006 |
Date Detail:
|
Created Date: 2006-02-07 Completed Date: 2006-06-07 Revised Date: 2012-06-26 |
Medline Journal Info:
|
Nlm Unique ID: 0370600 Medline TA: Annu Rev Physiol Country: United States |
Other Details:
|
Languages: eng Pagination: 29-49 Citation Subset: IM |
Affiliation:
|
Herman B Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5225, USA. mrubartv@iupui.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cell Cycle / physiology Cell Transplantation Heart / growth & development, physiology* Humans Myocardium / cytology Myocytes, Cardiac / physiology, transplantation Regeneration / physiology* |
| Grant Support | |
ID/Acronym/Agency:
|
P01 HL085098-01A1/HL/NHLBI NIH HHS; R01 HL075165/HL/NHLBI NIH HHS; R01 HL075165-02/HL/NHLBI NIH HHS; R01 HL083126-01/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Characterization of patients presenting for treatment to a university refractory periodontal disease...
Next Document: Endothelial-cardiomyocyte interactions in cardiac development and repair.