Document Detail


Cardiac regeneration: repopulating the heart.
MedLine Citation:
PMID:  16460265     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided that the newly formed myocytes structurally and functionally integrate in the preexisting myocardium. A number of approaches have been utilized to effect regenerative growth of the myocardium in experimental animals. These include interventions aimed at enhancing the ability of cardiomyocytes to proliferate in response to cardiac injury, as well as transplantation of cardiomyocytes or myogenic stem cells into diseased hearts. Here we review efforts to induce myocardial regeneration. We also provide a critical review of techniques currently used to assess cardiac regeneration and functional integration of de novo cardiomyocytes.
Authors:
Michael Rubart; Loren J Field
Related Documents :
2940815 - Electron microscopic autoradiographic study of heart muscle calcium in experimental car...
20863415 - Intracoronary delivery of bone-marrow-derived stem cells.
17628855 - Mesothelial cell transplantation in myocardial infarction.
20347795 - Intracoronary infusion of cd133+ endothelial progenitor cells improves heart function a...
1751115 - A sophisticated electromechanical ventricular simulator for ventricular assist system t...
23092255 - Stem cell therapy for the treatment of acute myocardial infarction and chronic ischemic...
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  68     ISSN:  0066-4278     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-06-07     Revised Date:  2013-10-22    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-49     Citation Subset:  IM    
Affiliation:
Herman B Wells Center for Pediatric Research and Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202-5225, USA. mrubartv@iupui.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cell Cycle / physiology
Cell Transplantation
Heart / growth & development,  physiology*
Humans
Myocardium / cytology
Myocytes, Cardiac / physiology,  transplantation
Regeneration / physiology*
Grant Support
ID/Acronym/Agency:
P01 HL085098-01A1/HL/NHLBI NIH HHS; R01 HL075165/HL/NHLBI NIH HHS; R01 HL075165-02/HL/NHLBI NIH HHS; R01 HL083126/HL/NHLBI NIH HHS; R01 HL083126-01/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Characterization of patients presenting for treatment to a university refractory periodontal disease...
Next Document:  Endothelial-cardiomyocyte interactions in cardiac development and repair.