Document Detail

Cardiac regeneration: repopulating the heart.
MedLine Citation:
PMID:  16460265     Owner:  NLM     Status:  MEDLINE    
Many forms of pediatric and adult heart disease result from a deficiency in cardiomyocyte number. Through repopulation of the heart with new cardiomyocytes (that is, induction of regenerative cardiac growth), cardiac disease potentially can be reversed, provided that the newly formed myocytes structurally and functionally integrate in the preexisting myocardium. A number of approaches have been utilized to effect regenerative growth of the myocardium in experimental animals. These include interventions aimed at enhancing the ability of cardiomyocytes to proliferate in response to cardiac injury, as well as transplantation of cardiomyocytes or myogenic stem cells into diseased hearts. Here we review efforts to induce myocardial regeneration. We also provide a critical review of techniques currently used to assess cardiac regeneration and functional integration of de novo cardiomyocytes.
Michael Rubart; Loren J Field
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Annual review of physiology     Volume:  68     ISSN:  0066-4278     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2006  
Date Detail:
Created Date:  2006-02-07     Completed Date:  2006-06-07     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-49     Citation Subset:  IM    
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MeSH Terms
Cell Cycle / physiology
Cell Transplantation
Heart / growth & development,  physiology*
Myocardium / cytology
Myocytes, Cardiac / physiology,  transplantation
Regeneration / physiology*
Grant Support
P01 HL085098/HL/NHLBI NIH HHS; P01 HL085098-01A1/HL/NHLBI NIH HHS; R01 HL075165/HL/NHLBI NIH HHS; R01 HL075165-02/HL/NHLBI NIH HHS; R01 HL083126/HL/NHLBI NIH HHS; R01 HL083126-01/HL/NHLBI NIH HHS

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