Document Detail

Cardiac regeneration: the gene therapy approach.
MedLine Citation:
PMID:  19344279     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Ischemic heart disease often results in myocardial infarction, after which surviving tissue undergoes remodeling. Unfortunately, the regenerative capacity of adult cardiomyocytes is poor. Repopulating myocardium with contractile cells is an objective of regenerative medicine. The most investigated strategy is implantation of stem cells. An alternative approach is stimulating cardiomyocytes to re-enter the cell cycle and progress to mitosis and cytokinesis through gene-mediated interventions targeting cell cycle regulators, or by injecting genes coding for mitotic cytokines. OBJECTIVE/METHODS: To summarize work done and examine postnatal growth of the heart in small rodents and large mammals to emphasize the need for caution when extrapolating results from mice and rats to humans. RESULTS/CONCLUSIONS: Today we have evidence that under certain circumstances adult cardiomyocytes re-enter the cell cycle and advances to mitosis, The problem is that our current knowledge of the triggering phenomena and the cascade of events leading to cardiomyocyte mitosis is poor.
Rub??n P Laguens; Alberto J Crottogini
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Expert opinion on biological therapy     Volume:  9     ISSN:  1744-7682     ISO Abbreviation:  Expert Opin Biol Ther     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-06     Completed Date:  2010-01-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101125414     Medline TA:  Expert Opin Biol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  411-25     Citation Subset:  IM    
Favaloro University, Department of Pathology, Sol??s 453, 1078 Buenos Aires, Argentina.
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MeSH Terms
Gene Therapy / methods*,  trends
Myocardial Infarction / genetics,  pathology,  physiopathology,  therapy
Myocytes, Cardiac / cytology,  pathology*,  transplantation
Regeneration / physiology*

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