| Cardiac regeneration: the gene therapy approach. | |
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MedLine Citation:
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PMID: 19344279 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Ischemic heart disease often results in myocardial infarction, after which surviving tissue undergoes remodeling. Unfortunately, the regenerative capacity of adult cardiomyocytes is poor. Repopulating myocardium with contractile cells is an objective of regenerative medicine. The most investigated strategy is implantation of stem cells. An alternative approach is stimulating cardiomyocytes to re-enter the cell cycle and progress to mitosis and cytokinesis through gene-mediated interventions targeting cell cycle regulators, or by injecting genes coding for mitotic cytokines. OBJECTIVE/METHODS: To summarize work done and examine postnatal growth of the heart in small rodents and large mammals to emphasize the need for caution when extrapolating results from mice and rats to humans. RESULTS/CONCLUSIONS: Today we have evidence that under certain circumstances adult cardiomyocytes re-enter the cell cycle and advances to mitosis, The problem is that our current knowledge of the triggering phenomena and the cascade of events leading to cardiomyocyte mitosis is poor. |
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Authors:
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Rub??n P Laguens; Alberto J Crottogini |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Expert opinion on biological therapy Volume: 9 ISSN: 1744-7682 ISO Abbreviation: Expert Opin Biol Ther Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-04-06 Completed Date: 2010-01-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101125414 Medline TA: Expert Opin Biol Ther Country: England |
Other Details:
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Languages: eng Pagination: 411-25 Citation Subset: IM |
Affiliation:
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Favaloro University, Department of Pathology, Sol??s 453, 1078 Buenos Aires, Argentina. rlaguens@ffavaloro.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Therapy / methods*, trends Humans Myocardial Infarction / genetics, pathology, physiopathology, therapy Myocytes, Cardiac / cytology, pathology*, transplantation Regeneration / physiology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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