| Cardiac, pulmonary and neuromuscular effects of clenbuterol and terbutaline compared with placebo. | |
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MedLine Citation:
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PMID: 7306434 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Cardiac, neuromuscular (tremor) and pulmonary effects of multiple single oral doses of clenbuterol (40, 60 and 80 micrograms) and terbutaline (2.5 and 5 mg) were compared with placebo in thirteen patients with reversible obstructive airways disease. 2 The percent change in the bronchodilator and neuromuscular effects of clenbuterol and terbutaline were greater than that of the cardiac activity. 3 Both drugs decreased T wave amplitude and occasionally caused J point ST segment depression. These changes were considered typical of this class of drugs and clinically insignificant. 4 While these drugs had comparable cardiac, pulmonary and neuromuscular effects, clenbuterol, at larger doses, had a higher incidence of transient headaches and nervousness. |
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Authors:
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T L Whitsett; C V Manion; M F Wilson |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 12 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1982-02-12 Completed Date: 1982-02-12 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 195-200 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Clenbuterol / adverse effects* Electrocardiography Ethanolamines / adverse effects* Female Heart / drug effects* Humans Lung / drug effects* Male Middle Aged Neuromuscular Junction / drug effects* Terbutaline / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Ethanolamines; 23031-25-6/Terbutaline; 37148-27-9/Clenbuterol |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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