Document Detail


Cardiac, pulmonary and neuromuscular effects of clenbuterol and terbutaline compared with placebo.
MedLine Citation:
PMID:  7306434     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 Cardiac, neuromuscular (tremor) and pulmonary effects of multiple single oral doses of clenbuterol (40, 60 and 80 micrograms) and terbutaline (2.5 and 5 mg) were compared with placebo in thirteen patients with reversible obstructive airways disease. 2 The percent change in the bronchodilator and neuromuscular effects of clenbuterol and terbutaline were greater than that of the cardiac activity. 3 Both drugs decreased T wave amplitude and occasionally caused J point ST segment depression. These changes were considered typical of this class of drugs and clinically insignificant. 4 While these drugs had comparable cardiac, pulmonary and neuromuscular effects, clenbuterol, at larger doses, had a higher incidence of transient headaches and nervousness.
Authors:
T L Whitsett; C V Manion; M F Wilson
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  British journal of clinical pharmacology     Volume:  12     ISSN:  0306-5251     ISO Abbreviation:  Br J Clin Pharmacol     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1982-02-12     Completed Date:  1982-02-12     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7503323     Medline TA:  Br J Clin Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  195-200     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Clenbuterol / adverse effects*
Electrocardiography
Ethanolamines / adverse effects*
Female
Heart / drug effects*
Humans
Lung / drug effects*
Male
Middle Aged
Neuromuscular Junction / drug effects*
Terbutaline / adverse effects*
Chemical
Reg. No./Substance:
0/Ethanolamines; 23031-25-6/Terbutaline; 37148-27-9/Clenbuterol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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