Document Detail


Cardiac preload and venous return in swimming sea bass (Dicentrarchus labrax L.).
MedLine Citation:
PMID:  15879073     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cardiac preload (central venous pressure, P(CV), mean circulatory filling pressure (MCFP), dorsal aortic blood pressure (P(DA)) and relative cardiac output (Q) were measured in sea bass (Dicentrarchus labrax) at rest and while swimming at 1 and 2 BL s(-1). MCFP, an index of venous capacitance and the upstream venous pressure driving the return of venous blood to the heart, was measured as the plateau in Pcv during ventral aortic occlusion. Compared with resting values, swimming at 1 and 2 BL s(-1) increased Q (by 15+/-1.5 and 38+/-6.5%, respectively), P(CV) (from 0.11+/-0.01 kPa to 0.12+/-0.01 and 0.16+/-0.02 kPa, respectively), MCFP (from 0.27+/-0.02 kPa to 0.31+/-0.02 and 0.40+/-0.04 kPa, respectively) and the calculated pressure gradient for venous return (DeltaP(V), from 0.16+/-0.01 kPa to 0.18+/-0.02 and 0.24+/-0.02 kPa, respectively), but not P(DA). In spite of an increased preload, the increase in Q was exclusively mediated by an increased heart rate (f(H), from 80+/-4 beats min(-1) to 88+/-4 and 103+/-3 beats min(-1), respectively), and stroke volume (Vs) remained unchanged. Prazosin treatment (1 mg kg(-1) Mb) abolished pressure and flow changes during swimming at 1 BL s(-1), but not 2 BL s(-1), indicating that other control systems besides an alpha-adrenoceptor control are involved. This study is the first to address the control of venous capacitance in swimming fish. It questions the generality that increased Q during swimming is regulated primarily through Vs and shows that an increased cardiac filling pressure does not necessarily lead to an increased Vs in fish, but may instead compensate for a reduced cardiac filling time.
Authors:
Erik Sandblom; Anthony P Farrell; Jordi Altimiras; Michael Axelsson; Guy Claireaux
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of experimental biology     Volume:  208     ISSN:  0022-0949     ISO Abbreviation:  J. Exp. Biol.     Publication Date:  2005 May 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0243705     Medline TA:  J Exp Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1927-35     Citation Subset:  IM    
Affiliation:
Department of Zoology, Göteborg University, Box 463, S-405 30 Göteborg, Sweden. erik.sandbolm@zool.gu.se
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MeSH Terms
Descriptor/Qualifier:
Animals
Bass / physiology*
Blood Circulation / drug effects,  physiology*
Blood Pressure / drug effects,  physiology
Cardiac Output / drug effects,  physiology
Heart / physiology*
Heart Function Tests
Heart Rate
Prazosin / pharmacology
Stroke Volume
Swimming / physiology*
Vascular Capacitance / physiology*
Veins / physiology*
Chemical
Reg. No./Substance:
19216-56-9/Prazosin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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