Document Detail

Cardiac preconditioning with local laser-induced hyperthermia.
MedLine Citation:
PMID:  18657832     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Whole body hyperthermia has been shown to be highly effective in preconditioning cardiac tissue against reperfusion injury. The current study was aimed to assess the ability of regional sublethal laser-induced hyperthermia to precondition cardiac tissue against ischemic-induced myocardial infarction. METHODS AND RESULTS: Diode laser radiation was used to locally heat (42 degrees C) the left ventricle by irradiating the epicardial surface of rat heart for 20 min. As control, another group of animals were treated with whole-body hyperthermia (WBH) for 20 min. After a 4-h recovery period, the left coronary artery was occluded for 30 min followed by 4 h of reperfusion. A significant degree of reduction in infarct size as assessed by percent of at-risk area was observed in animals that were subjected to laser-induced local hyperthermia (15.4 +/- 3.1; n = 5) versus the sham group (49.8 +/- 6.6; n = 5). The degree of cardiac protection induced by local hyperthermia was similar to the protection observed when the animals were preconditioned with WBH. Furthermore, regional laser-induced hyperthermia and WBH induced similar degree of up-regulation of heat shock protein 70 in cardiac tissue. Regional hyperthermia up-regulated heat shock protein in regions of the heart beyond that directly subjected to laser-induced heat stress. CONCLUSION: Sublethal local heating of the heart with diode laser irradiation can improve myocardial salvage and may provide a practical approach for tissue preconditioning against reperfusion injury.
Bin Gong; Brent Bell; Paul J Boor; Thomas B Albrecht; Gregory K Asimakis; Massoud Motamedi
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-25
Journal Detail:
Title:  The Journal of surgical research     Volume:  149     ISSN:  1095-8673     ISO Abbreviation:  J. Surg. Res.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-09-15     Completed Date:  2008-10-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  177-83     Citation Subset:  IM    
Center of Biomedical Engineering, Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77555-0456, USA.
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MeSH Terms
Body Temperature
HSP70 Heat-Shock Proteins / metabolism*
Hyperthermia, Induced / methods*
Ischemic Preconditioning, Myocardial / methods*
Lasers, Semiconductor*
Rats, Sprague-Dawley
Reg. No./Substance:
0/HSP70 Heat-Shock Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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