| Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations. | |
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MedLine Citation:
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PMID: 19021936 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Concomitant heart and peripheral blood determinations were performed on 40 fatal cases involving nordiazepam (20 cases) and bromazepam (20 cases). The heart blood concentration for the two drugs (588 ng/mL for nordiazepam and 802 ng/mL for bromazepam) does not differ from the corresponding peripheral blood concentration (587 ng/mL for nordiazepam and 883 ng/mL for bromazepam). The mean ratios for the heart and peripheral blood concentrations were 0.95 for nordiazepam and 0.86 for bromazepam. No postmortem redistribution was observed for these two benzodiazepines. The authors thus suggest that corresponding heart blood can be proposed in the quantitative analysis of these drugs when peripheral blood is unavailable. The present study also shows the stability of the two drugs after a year of storage. |
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Authors:
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P-Rop Pos Pok; Djamel Haddouche; Michel Mauras; Erika Kuhlmann; Joëlle Burle; Thierry Salmon; Emilie Berland; P-Emmanuel Coiffait; Alain Viala |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of analytical toxicology Volume: 32 ISSN: 0146-4760 ISO Abbreviation: J Anal Toxicol Publication Date: 2008 Nov-Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-01-06 Revised Date: 2009-12-15 |
Medline Journal Info:
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Nlm Unique ID: 7705085 Medline TA: J Anal Toxicol Country: United States |
Other Details:
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Languages: eng Pagination: 782-6 Citation Subset: IM |
Affiliation:
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INPS, Laboratoire de Police Scientifique de Marseille, Section Toxicologie, 97, boulevard Camille Flammarion, BP30, 13245 Marseille, France. rop-pos.pok@interieur.gouv.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Anxiety Agents / analysis*, blood*, pharmacokinetics Biotransformation Bromazepam / analogs & derivatives, analysis*, blood*, pharmacokinetics Chromatography, High Pressure Liquid Female Humans Male Myocardium / chemistry* Nordazepam / analysis*, blood*, pharmacokinetics Oxazepam / analysis, blood Spectrophotometry, Ultraviolet |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 1088-11-5/Nordazepam; 13132-73-5/3-hydroxybromazepam; 1812-30-2/Bromazepam; 604-75-1/Oxazepam |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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