| Cardiac performance of isolated beating hearts obtained from rats anesthetized by three different agents. | |
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MedLine Citation:
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PMID: 3999698 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Two functional performance parameters (heart rate and coronary flow rate) of three groups of six isolated beating hearts obtained from rats anesthetized by inhalation of diethyl ether in air, injection intraperitoneally of sodium pentobarbital (60mg/kg) or intravenously of alphaxalone/alphadolone (15mg/kg) were compared. Differences were small, but alphaxalone-alphadolone showed lowest stable mean coronary flow rate and diethyl ether the widest variation between animals. No significant difference in function was found between ether and pentobarbital, currently the two most widely used methods. But, pentobarbital showed higher stable functional performance and least variation between animals. We conclude that pentobarbital is the most useful of these three agents for obtaining hearts for perfusion as isolated beating organs, and that alphaxalone-alphadolone is clearly less suitable. |
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Authors:
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M D Sage; E J West; J B Gavin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Laboratory animal science Volume: 35 ISSN: 0023-6764 ISO Abbreviation: Lab. Anim. Sci. Publication Date: 1985 Apr |
Date Detail:
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Created Date: 1985-07-08 Completed Date: 1985-07-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1266503 Medline TA: Lab Anim Sci Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 153-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia* Animals Coronary Circulation Ether, Ethyl* Ethyl Ethers* Heart / physiology* Heart Rate Pentobarbital* Pregnanediones Rats |
| Chemical | |
Reg. No./Substance:
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0/Ethyl Ethers; 0/Pregnanediones; 14107-37-0/alphadolone; 23930-19-0/alphaxalone; 60-29-7/Ether, Ethyl; 76-74-4/Pentobarbital |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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