Document Detail

Cardiac performance in inbred rat genetic models of low and high running capacity.
MedLine Citation:
PMID:  11533149     Owner:  NLM     Status:  MEDLINE    
1. Previous work demonstrating that DA inbred rats are superior to COP inbred rats in aerobic treadmill running capacity has indicated their utility as genetic models to explore this trait. We tested the general hypothesis that intermediate phenotypes of cardiac function and calcium metabolism are responsible for the difference in capacity between these strains. 2. Logical cardiac trait differences were estimated at a tissue (isolated papillary muscle), cellular (isolated left ventricular cells), and biochemical level of organization. 3. DA hearts were found to give significantly higher values than COP hearts for: (1) maximal developed tension (38.3 % greater), and rates of tension change in contraction (61 %) or relaxation (59 %) of isolated papillary muscle, (2) fractional shortening (50 %), amplitude of the Ca(2+) transient (78.6 %), and caffeine-induced release of Ca(2+) from the sarcoplasmic reticulum (SR; 260 %) in isolated ventricular myocytes, and (3) Na(+),K(+)-ATPase activity of isolated myocytes (17.3 %). 4. Our results suggest that these trait differences may prove useful for further studies into the genes responsible for natural variations in both ventricular function and aerobic endurance capacity. Understanding the genetic basis of aerobic capacity will help define the continuum between health and disease.
J Chen; G M Feller; J C Barbato; S Periyasamy; Z J Xie; L G Koch; J I Shapiro; S L Britton
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of physiology     Volume:  535     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-04     Completed Date:  2001-12-04     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  611-7     Citation Subset:  IM    
Functional Genomics Laboratory, Medical College of Ohio, Toledo, OH 43614-5804, USA.
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MeSH Terms
Calcium / metabolism
Cells, Cultured
Exercise Tolerance / genetics*
Heart / physiology*
Heart Ventricles / cytology
Models, Animal
Muscle Contraction / physiology
Muscle Fibers, Skeletal / enzymology
Myocardial Contraction / genetics*
Papillary Muscles / cytology,  physiology
Rats, Inbred Strains / physiology*
Sodium-Potassium-Exchanging ATPase / metabolism
Ventricular Function
Grant Support
Reg. No./Substance:
7440-70-2/Calcium; EC ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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