| Cardiac pathologies in relation to Smad-dependent pathways. | |
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MedLine Citation:
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PMID: 20650957 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transforming growth factor-β (TGF-β) superfamily are of structurally related proteins that mediate developmental processes including cell growth, apoptosis, cellular homeostasis, tissue differentiation, morphogenesis, proliferation, and migration. Smads are intracellular signaling effectors that mediate intracellular signaling of the TGF-β superfamily. They have been implicated in a wide range of cardiac disorders, including cardiac failure, cardiac fibrosis, myocardial infarction, injury induced by angioplasty, and pulmonary artery hypertension. They also have a function to regulate cardiac structural development in embryos. By binding to types I and II of serine-threonine kinase receptors, bone morphogenetic protein 2 (BMP2) enables phosphorylation of Smad1 to form hetero-oligomeric complexes with Smad4, and modulate the transcription of the target genes after they are translocated into the nucleus. Appropriate interventions, such as Smad-responsive transcriptional promoter and antifibrotic angiotensin-converting enzyme inhibitors, can be helpful in reversing cardiac abnormalities. The aim of this article is to describe the current research results of Smad proteins in terms of cardiac disorders and development through transforming growth factor (TGF)-β pathways. |
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Authors:
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Shi-Min Yuan; Hua Jing |
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Publication Detail:
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Type: Journal Article Date: 2010-07-22 |
Journal Detail:
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Title: Interactive cardiovascular and thoracic surgery Volume: 11 ISSN: 1569-9285 ISO Abbreviation: Interact Cardiovasc Thorac Surg Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-22 Completed Date: 2011-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101158399 Medline TA: Interact Cardiovasc Thorac Surg Country: England |
Other Details:
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Languages: eng Pagination: 455-60 Citation Subset: IM |
Affiliation:
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Department of Cardiothoracic Surgery, Jinling Hospital, School of Clinical Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bone Morphogenetic Proteins
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metabolism Cardiovascular Diseases / metabolism*, physiopathology Humans Signal Transduction Smad Proteins / metabolism* Transforming Growth Factor beta / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Proteins; 0/Smad Proteins; 0/Transforming Growth Factor beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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