| Cardiac pathologic findings reveal a high rate of sudden cardiac death of undetermined etiology in younger women. | |
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MedLine Citation:
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PMID: 14564316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Between 1989 and 1998 there was a 21% increase in estimated sudden cardiac death among US women aged 35 to 44 years. In contrast, the sudden cardiac death rate in age-matched men showed a decreasing trend (-2.8%). Due to under-representation of younger adults in published autopsy series, etiologies of sudden cardiac death merit further investigation. METHODS: We reviewed autopsy and detailed cardiac pathologic findings in younger women (age 35-44 years) from a 270-patient, 13-year (1984-1996) autopsy series of sudden cardiac death, and performed comparisons with findings in age-matched men. RESULTS: Women aged 35 to 44 years constituted 32% of all women in the series compared to men, who constituted 24% of total men (P =.004 vs women). A presumptive cause of sudden cardiac death could not be determined in 13 women (50%). Among women, 6 cases (22%) had significant coronary artery disease. Findings in others included coronary artery anomalies (n = 3), myocarditis (n = 2), hypertrophic cardiomyopathy (n = 1), coronary artery dissection (n = 1) and accessory pathway (n = 1). In younger men, a presumptive cause of sudden cardiac death remained undetermined in only 24% (P =.025 vs younger women), and coronary artery disease accounted for 40% of cases. CONCLUSIONS: In younger women, despite autopsy and detailed cardiac pathologic examination, an attributable cause of sudden cardiac death was not determined in 50% of cases; a 2-fold increase compared to men of the same age. Given the dynamic and multifactorial nature of sudden cardiac death, comprehensive population-based investigations are likely to be necessary to further investigate this unexpected sex-based disparity. |
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Authors:
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Sumeet S Chugh; Kiyon Chung; Zhi-Jie Zheng; Benjamin John; Jack L Titus |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: American heart journal Volume: 146 ISSN: 1097-6744 ISO Abbreviation: Am. Heart J. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-17 Completed Date: 2003-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370465 Medline TA: Am Heart J Country: United States |
Other Details:
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Languages: eng Pagination: 635-9 Citation Subset: AIM; IM |
Affiliation:
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Division of Cardiology, Oregon Health and Science University, Portland, Ore 97239, USA. chughs@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Autopsy Coronary Disease / pathology* Death, Sudden, Cardiac / etiology, pathology* Female Humans Hypertrophy, Left Ventricular / pathology* Male Mitral Valve Prolapse / pathology* Myocardium / pathology |
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