Document Detail

Cardiac parasympathetic dysfunction concurrent with cardiac sympathetic denervation in Parkinson's disease.
MedLine Citation:
PMID:  18838148     Owner:  NLM     Status:  MEDLINE    
We aimed to characterize the relationship between cardiac sympathetic and parasympathetic dysfunction employing cardiac (123)I-meta-iodobenzylguanidine (MIBG) uptake and other autonomic function parameters in Parkinson's disease (PD). 79 PD patients were studied. We performed (123)I-MIBG myocardial scintigraphy to assess the extent of cardiac sympathetic denervation. Electrocardiogram readings at rest and postural change in blood pressure were also examined. Coefficient variation of RR intervals (CVR-R) was used as an index for cardiac parasympathetic activity. Cardiac (123)I-MIBG uptake did not vary significantly among the Hoehn-Yahr (H-Y) stages. There was a significant correlation between cardiac (123)I-MIBG uptake and CVR-R (early, r=0.457, p<0.001; late, r=0.442, p<0.001). While the correlation was present among the patients who had had the disease less than two years (early, r=0.558, p<0.001; late, r=0.530, p<0.001), the patients with the disease duration longer than two years did not have such a significant correlation. Age, disease duration, corrected QT interval, or postural blood pressure change did not correlate with cardiac (123)I-MIBG uptake. Orthostatic hypotension was observed in 13 out of 72 subjects, and reduced CVR-R was a major determinant for the development of orthostatic hypotension. We conclude that cardiac parasympathetic dysfunction occurs concurrent with sympathetic denervation as revealed by (123)I-MIBG myocardial scintigraphy in PD and contributes to the development of orthostatic hypotension.
Mamoru Shibata; Yoko Morita; Toshihiko Shimizu; Kazushi Takahashi; Norihiro Suzuki
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Publication Detail:
Type:  Journal Article     Date:  2008-10-05
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  276     ISSN:  0022-510X     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-12     Completed Date:  2009-03-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  79-83     Citation Subset:  IM    
Department of Neurology, National Hospital Organization Tokyo Medical Center, Tokyo, Japan.
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MeSH Terms
3-Iodobenzylguanidine / diagnostic use
Aged, 80 and over
Analysis of Variance
Autonomic Nervous System Diseases / etiology*,  radionuclide imaging
Chi-Square Distribution
Electrocardiography / methods
Hypotension, Orthostatic / etiology,  radionuclide imaging
Linear Models
Middle Aged
Myocardial Perfusion Imaging / methods
Myocardium / pathology*
Parkinson Disease / complications*,  radionuclide imaging
Radiopharmaceuticals / diagnostic use
Reg. No./Substance:
0/Radiopharmaceuticals; 77679-27-7/3-Iodobenzylguanidine

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