| Cardiac output response to changes of the atrioventricular delay in different body positions and during exercise in patients receiving cardiac resynchronization therapy. | |
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MedLine Citation:
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PMID: 19578177 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: The aim of this study was to study the haemodynamic effect of atrioventricular delay (AVD) modifications within a narrow range in different body positions and during exercise in patients receiving cardiac resynchronization therapy (CRT). METHODS: The previously optimized AVD was shortened and prolonged by 40 ms in 27 CRT patients and 9 controls without heart failure. Cardiac output (CO) was measured by inert gas rebreathing (Innocor) as the average over different body positions (left-lateral, supine, sitting, standing, and exercise). In eight CRT patients with an implantable haemodynamic monitor, the estimated pulmonary artery diastolic pressure (ePAD) was analysed. RESULTS: The magnitude of CO response to AVD changes was greater in CRT patients than in controls (0.25 vs. 0.20 L/min, P<0.05), varied substantially between individuals (range: 0.12-0.56 L/min), and correlated with left atrial size (r=0.61, P<0.001). On average, AVD shortening decreased CO slightly (0.07+/-0.17 L/min) and increased ePAD (1.1+/-0.8 mmHg, both P<0.05), whereas prolongation had no significant effect. CONCLUSION: The haemodynamic response to AVD modifications within a narrow range is larger in CRT patients than in normal controls and varies substantially between individuals. These findings suggest that optimal AVD tuning is clinically important in selected patients. |
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Authors:
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Marcus Ståhlberg; Morten Damgaard; Peter Norsk; Anders Gabrielsen; Anders Sahlén; Cecilia Linde; Frieder Braunschweig |
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Publication Detail:
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Type: Comparative Study; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-04 |
Journal Detail:
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Title: Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology Volume: 11 ISSN: 1532-2092 ISO Abbreviation: - Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-26 Completed Date: 2009-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883649 Medline TA: Europace Country: England |
Other Details:
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Languages: eng Pagination: 1160-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Karolinska Institutet, Karolinska University Hospital, S-17176 Stockholm, Sweden. marcus.stahlberg@ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Atrioventricular Node / physiopathology* Cardiac Output* Cardiac Pacing, Artificial* Female Heart Failure / physiopathology*, prevention & control* Heart Rate* Humans Male Physical Exertion* Posture* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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