| Cardiac output and regional hemodynamics during recurrent seizures in rats. | |
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MedLine Citation:
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PMID: 8281438 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Altered cardiovascular function in status epilepticus may contribute to mortality and morbidity in patients. We investigated changes in cardiac output and regional hemodynamics during 2 h of recurrent PTZ-induced seizures in anesthetized, paralyzed rats using radioactive microspheres, thermodilution methods, and the pulsed Doppler technique. Cardiac output fell 30-60% during recurrent seizures in 17 of 27 animals. The fall in cardiac output was sudden in onset and occurred primarily in association with seizures accompanied by prolonged increases in MABP but no change in central venous pressure. Total peripheral resistance (TPR) rose during early seizures in association with vasoconstriction of renal and certain splanchnic vascular beds. Ictal increases in TPR became attenuated during late seizures, due to failure of renal and splanchnic beds to constrict. Therefore, derangements in both cardiac and vascular function occur during late seizures. These derangements may contribute to both cerebral hypoperfusion and sudden death in status epilepticus. |
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Authors:
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N R Kreisman; M L Gauthier-Lewis; S G Conklin; N F Voss; R W Barbee |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 626 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1993 Oct |
Date Detail:
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Created Date: 1994-02-14 Completed Date: 1994-02-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 295-302 Citation Subset: IM |
Affiliation:
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Department of Physiology (SL-39), Tulane University School of Medicine, New Orleans, LA 70112. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / physiology Cardiac Output* Hemodynamics / physiology* Male Rats Rats, Wistar Seizures / physiopathology* Status Epilepticus / physiopathology* Vascular Resistance / physiology |
| Grant Support | |
ID/Acronym/Agency:
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HL 29952/HL/NHLBI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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