Document Detail

Cardiac output and end-tidal carbon dioxide.
MedLine Citation:
PMID:  3931979     Owner:  NLM     Status:  MEDLINE    
Previous studies demonstrated selective increases in mixed venous carbon dioxide tension (PvCO2) during CPR in a porcine model of cardiac arrest. This was associated with a decrease in end-tidal carbon dioxide concentration (ETCO2), possibly due to a critical reduction in cardiac output and therefore pulmonary blood flow during CPR. We investigated the relationship between ETco2 and cardiac output before cardiac arrest and during CPR. Observations in 19 minipigs confirmed a high linear correlation between ETco2 and cardiac output. We conclude that the increase in Pvco2 and the concurrent decrease in ETco2 reflect a critical reduction in cardiac output, which reduces alveolar blood flow to the extent that carbon dioxide clearance by the lung fails to keep pace with systemic CO2 production.
M H Weil; J Bisera; R P Trevino; E C Rackow
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  13     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-12-02     Completed Date:  1985-12-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  907-9     Citation Subset:  AIM; IM    
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MeSH Terms
Carbon Dioxide / analysis*
Cardiac Output*
Heart Arrest / physiopathology*,  therapy
Monitoring, Physiologic / methods*
Tidal Volume
Reg. No./Substance:
124-38-9/Carbon Dioxide

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