Document Detail


Cardiac output effects of endothelin-1, -2 and -3 and sarafotoxin S6b in conscious rats.
MedLine Citation:
PMID:  2196309     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Conscious, Long-Evans rats, chronically-instrumented for the direct measurement of intra-arterial and central venous pressures and ascending aortic blood flow (i.e. cardiac output), were given bolus, intravenous doses (4 and 40 pmol) of endothelin-1, -2, or -3 or sarafotoxin S6b in random order. The lower dose of endothelin-1 and -3 and sarafotoxin S6b caused a significant increase in cardiac output. The higher bolus dose of the same three peptides caused initial hypotension and increases in cardiac output, stroke volume and total peripheral conductance. Endothelin-2 did not have these initial effects in all animals. Subsequently, all peptides increased mean arterial blood pressure and decreased cardiac output and total peripheral conductance. Overall the effects of endothelin-1 and sarafotoxin S6b were very similar, consistent with them acting at the same site.
Authors:
S M Gardiner; A M Compton; P A Kemp; T Bennett
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  30     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, U.K.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aorta, Thoracic / physiology
Blood Pressure / drug effects
Cardiac Output / drug effects*
Dose-Response Relationship, Drug
Endothelins
Endothelium, Vascular / metabolism
Heart Rate / drug effects
Male
Peptides / pharmacology*
Rats
Rats, Inbred Strains
Regional Blood Flow
Stroke Volume / drug effects
Vasoconstrictor Agents / pharmacology
Viper Venoms / pharmacology*
Chemical
Reg. No./Substance:
0/Endothelins; 0/Peptides; 0/Vasoconstrictor Agents; 0/Viper Venoms; 0/sarafotoxins s6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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