Document Detail

Cardiac output effects of endothelin-1, -2 and -3 and sarafotoxin S6b in conscious rats.
MedLine Citation:
PMID:  2196309     Owner:  NLM     Status:  MEDLINE    
Conscious, Long-Evans rats, chronically-instrumented for the direct measurement of intra-arterial and central venous pressures and ascending aortic blood flow (i.e. cardiac output), were given bolus, intravenous doses (4 and 40 pmol) of endothelin-1, -2, or -3 or sarafotoxin S6b in random order. The lower dose of endothelin-1 and -3 and sarafotoxin S6b caused a significant increase in cardiac output. The higher bolus dose of the same three peptides caused initial hypotension and increases in cardiac output, stroke volume and total peripheral conductance. Endothelin-2 did not have these initial effects in all animals. Subsequently, all peptides increased mean arterial blood pressure and decreased cardiac output and total peripheral conductance. Overall the effects of endothelin-1 and sarafotoxin S6b were very similar, consistent with them acting at the same site.
S M Gardiner; A M Compton; P A Kemp; T Bennett
Related Documents :
11347409 - Toward a new method of analyzing cardiac performance.
10794329 - The effects of transesophageal echocardiography on hemodynamic variables in small infan...
6225409 - Noninvasive intraoperative assessment of arterial reconstruction. experimental validati...
9124659 - Continuous versus intermittent thermodilution cardiac output measurement during orthoto...
1974129 - Cardiovascular and neurohumoral responses following burn injury.
11524049 - Haemodynamics of the pressor effect of oral water in human sympathetic denervation due ...
21800889 - Pressure-dependent ion current rectification in conical-shaped glass nanopores.
2183109 - The effects of epidural anesthesia on the doppler velocimetry of umbilical and uterine ...
7606259 - Wavelet analysis of arterial pressure and blood velocity pulsations in the aorta of ane...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  30     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1990 Jun 
Date Detail:
Created Date:  1990-08-23     Completed Date:  1990-08-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  143-7     Citation Subset:  IM    
Department of Physiology and Pharmacology, Queen's Medical Centre, Nottingham, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Aorta, Thoracic / physiology
Blood Pressure / drug effects
Cardiac Output / drug effects*
Dose-Response Relationship, Drug
Endothelium, Vascular / metabolism
Heart Rate / drug effects
Peptides / pharmacology*
Rats, Inbred Strains
Regional Blood Flow
Stroke Volume / drug effects
Vasoconstrictor Agents / pharmacology
Viper Venoms / pharmacology*
Reg. No./Substance:
0/Endothelins; 0/Peptides; 0/Vasoconstrictor Agents; 0/Viper Venoms; 0/sarafotoxins s6

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Resource-based relative value scale: a new payment system for practitioners under Medicare.
Next Document:  Pulmonary vagal sensory afferents and spontaneous EEG rhythms in the cat sensorimotor cortex.