Document Detail

Cardiac output changes secondary to theophylline therapy in preterm infants.
MedLine Citation:
PMID:  3772667     Owner:  NLM     Status:  MEDLINE    
The cardiovascular effects of theophylline were studied in 11 clinically stable preterm infants. Theophylline was given as aminophylline using a loading dose of 6.8 mg/kg and a maintenance dose of 2 mg/kg every 8 hours intravenously. Cardiac output, stroke volume, and heart rate were measured using a combination of pulsed Doppler ultrasound and M-mode echocardiography. Compared with day 0, an increase was found in both cardiac output (P less than 0.01) and stroke volume (P less than 0.02) on days 1, 2, and 3. By day 7, stroke volume was comparable to pretreatment values, whereas cardiac output was still increased. Heart rate was augmented significantly (P less than 0.01) throughout the treatment period. Mean arterial blood pressure did not change. All but one of the neonates had serum theophylline concentrations between 6 and 13 mg/L. We conclude that both inotropic and chronotropic effects are evident during the first days of theophylline therapy. The metabolic cost of the increased cardiac output in the preterm infant with theophylline therapy deserves further attention.
F J Walther; M E Sims; B Siassi; P Y Wu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  109     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1986 Nov 
Date Detail:
Created Date:  1986-12-03     Completed Date:  1986-12-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  874-6     Citation Subset:  AIM; IM    
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MeSH Terms
Aminophylline / pharmacology,  supply & distribution,  therapeutic use
Blood Pressure / drug effects
Cardiac Output / drug effects*
Heart Rate / drug effects
Infant, Newborn
Infant, Premature, Diseases / drug therapy*,  physiopathology
Myocardial Contraction / drug effects
Stimulation, Chemical
Stroke Volume / drug effects
Theophylline / administration & dosage,  pharmacology,  therapeutic use*
Reg. No./Substance:
317-34-0/Aminophylline; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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